C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) (AA 101-115) antibody

Antigen: C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf)

Synonyms: VEGFD, VEGF-D, FIGF, vegfd, vegf-d, Vegfd, AI325264, Vegf-d

Binding Site: AA 101-115

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN967243

Additional Information

Alternative name: VEGFD

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human VEGFD (101-115aa), identical to the related rat sequence.

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Description: C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. Analyzing by Northern blotting, Yamada et al. (1997) symbolized VEGFD, was expressed as a 2.2-kb transcript with highest expression in lung, heart, small intestine, and fetal lung, and lower levels in skeletal muscle, colon, and pancreas. And Achen et al. (1998) concluded that VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. Stacker et al. (2001) showed that VEGFD can induce tumor angiogenesis through VEGFR2 and tumor lymphangiogenesis through VEGFR3, whereas VEGF, which does not activate VEGFR3, induces only tumor angiogenesis.

Application Details

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: 0.05mg Thiomersal, 0.05mg NaN3.

Storage: At -20°C for one year. After reconstitution, at 4°C for one month.

Research Area: Cancer, Angiogenesis, Growth Factors

Restrictions: For Research Use only

Publications

Product: Yamada, Nezu, Shimane et al.: "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D." in: Genomics, Vol. 42, Issue 3, pp. 483-8, 1997 (PubMed).

Achen, Jeltsch, Kukk et al.: "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 2, pp. 548-53, 1998 (PubMed).

Stacker, Caesar, Baldwin et al.: "VEGF-D promotes the metastatic spread of tumor cells via the lymphatics." in: Nature medicine, Vol. 7, Issue 2, pp. 186-91, 2001 (PubMed).