WWOX antibody (WW Domain Containing Oxidoreductase) (N-Term)

Details for Product anti-WWOX Antibody No. ABIN967262, Supplier: Log in to see
Antigen
  • CG7221
  • DmWWOX
  • Dmel\\CG7221
  • anon-EST:Posey177
  • GB11795
  • WWOX
  • D16S432E
  • FOR
  • FRA16D
  • HHCMA56
  • PRO0128
  • SDR41C1
  • WOX1
  • zgc:55975
  • 5330426P09Rik
  • 9030416C10Rik
  • WW domain containing oxidoreductase
  • WW domain-containing oxidoreductase
  • Wwox
  • WWOX
  • CpipJ_CPIJ004939
  • MCYG_01584
  • VDBG_05631
  • VDBG_01326
  • VDBG_06753
  • Tsp_03967
  • LOC100229880
  • LOC100284583
  • wwox
Epitope
N-Term
18
13
12
10
9
7
3
3
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
71
67
20
6
2
2
2
2
2
1
1
1
1
Host
Rabbit
83
3
3
Clonality
Polyclonal
Conjugate
This WWOX antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
83
36
26
15
12
9
6
5
4
3
2
1
1
1
Options
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human WWOX (WW domain-containing oxidoreductase)
Alternative Name WWOX (WWOX Antibody Abstract)
Background WWOX (WW domain-containing oxidoreductase) is a probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. WWOX may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. WWOX may also play a role in tumor necrosis factor (TNF)-mediated cell death.WWOX interacts with TP53, TP73/p73 and MAPK8. WWOX forms a ternary complex with TP53 and MDM2. WWOX is widely expressed and strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Defects in WWOX may be involved in several cancer types. Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC)
Synonyms: FOR, WOX1
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Alzheimer's Disease, Apoptosis/Necrosis
Restrictions For Research Use only
Product cited in: Park, Ludes-Meyers, Zimonjic, Durkin, Popescu, Aldaz: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." in: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, 2004 (PubMed).

Chang, Doherty, Ensign: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, 2003 (PubMed).

Bednarek, Keck-Waggoner, Daniel, Laflin, Bergsagel, Kiguchi, Brenner, Aldaz: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." in: Cancer research, Vol. 61, Issue 22, pp. 8068-73, 2001 (PubMed).

Paige, Taylor, Taylor, Hillier, Farrington, Scott, Porteous, Smyth, Gabra, Watson: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, 2001 (PubMed).

Bednarek, Laflin, Daniel, Liao, Hawkins, Aldaz: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." in: Cancer research, Vol. 60, Issue 8, pp. 2140-5, 2000 (PubMed).

Ried, Finnis, Hobson, Mangelsdorf, Dayan, Nancarrow, Woollatt, Kremmidiotis, Gardner, Venter, Baker, Richards: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." in: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, 2000 (PubMed).

Background publications Aqeilan, Palamarchuk, Weigel, Herrero, Pekarsky, Croce: "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor." in: Cancer research, Vol. 64, Issue 22, pp. 8256-61, 2004 (PubMed).