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WWOX antibody (WW Domain Containing Oxidoreductase) (N-Term)

Details for Product anti-WWOX Antibody No. ABIN967262, Supplier: Log in to see
Antigen
  • 5330426P09Rik
  • 9030416C10Rik
  • anon-EST:Posey177
  • CG7221
  • D16S432E
  • Dmel\\CG7221
  • DmWWOX
  • FOR
  • FRA16D
  • GB11795
  • HHCMA56
  • PRO0128
  • SDR41C1
  • WOX1
  • WWOX
  • zgc:55975
Epitope
N-Term
24
16
11
10
6
3
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
61
52
11
2
2
2
1
1
Host
Rabbit
74
3
3
Clonality
Polyclonal
Conjugate
This WWOX antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
72
37
21
9
8
6
5
4
4
3
2
1
1
Supplier
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Supplier Product No.
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Immunogen Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human WWOX (WW domain-containing oxidoreductase)
Alternative Name WWOX (WWOX Antibody Abstract)
Background WWOX (WW domain-containing oxidoreductase) is a probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. WWOX may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. WWOX may also play a role in tumor necrosis factor (TNF)-mediated cell death.WWOX interacts with TP53, TP73/p73 and MAPK8. WWOX forms a ternary complex with TP53 and MDM2. WWOX is widely expressed and strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Defects in WWOX may be involved in several cancer types. Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC)
Synonyms: FOR, WOX1
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Alzheimer's Disease, Apoptosis/Necrosis
Restrictions For Research Use only
Product cited in: Park, Ludes-Meyers, Zimonjic, Durkin, Popescu, Aldaz: "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma." in: British journal of cancer, Vol. 91, Issue 4, pp. 753-9, 2004

Chang, Doherty, Ensign: "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9195-202, 2003

Bednarek, Keck-Waggoner, Daniel, Laflin, Bergsagel, Kiguchi, Brenner, Aldaz: "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth." in: Cancer research, Vol. 61, Issue 22, pp. 8068-73, 2001

Paige, Taylor, Taylor, Hillier, Farrington, Scott, Porteous, Smyth, Gabra, Watson: "WWOX: a candidate tumor suppressor gene involved in multiple tumor types." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11417-22, 2001

Bednarek, Laflin, Daniel, Liao, Hawkins, Aldaz: "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer." in: Cancer research, Vol. 60, Issue 8, pp. 2140-5, 2000

Ried, Finnis, Hobson, Mangelsdorf, Dayan, Nancarrow, Woollatt, Kremmidiotis, Gardner, Venter, Baker, Richards: "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells." in: Human molecular genetics, Vol. 9, Issue 11, pp. 1651-63, 2000

Background publications Aqeilan, Palamarchuk, Weigel, Herrero, Pekarsky, Croce: "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor." in: Cancer research, Vol. 64, Issue 22, pp. 8256-61, 2004