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C-JUN antibody (Jun Proto-Oncogene) (C-Term)

Details for Product anti-JUN Antibody No. ABIN967394, Supplier: Log in to see
Antigen
  • BSK
  • BSK/DJNK
  • Bsk
  • CG5680
  • D-JNK
  • D-junk
  • DBSK/JNK
  • DJNK
  • DJNK/bsk
  • Dmel\\CG5680
  • JNK
  • JNK/SAPK
  • Jnk
  • Junk
  • SAPKa
  • c-Jun
  • dJNK
  • jnk
  • Jun
  • AP-1
  • JUN
  • B230310J22Rik
  • p39
  • Junc
  • c-jun
  • AP1
  • fj36h07
  • wu:fj36h07
  • zgc:65863
  • CG2275
  • D-Jun
  • D-jun
  • D-jun/Jra
  • DJUN
  • DJun
  • Djun
  • Dmel\\CG2275
  • JRA
  • V
  • cJun
  • d-JRA
  • d-Jun
  • d-jun
  • dAP-1
  • dJRA
  • dJUN
  • dJra
  • dJun
  • djun
  • dm-Jun
  • jra
  • jun
  • l(2)46Ef
  • l(2)IA109
  • l(2R)IA109
Alternatives
anti-Human C-JUN antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
73
59
44
42
41
40
40
34
23
20
19
18
13
13
13
13
11
11
8
8
8
8
6
6
6
5
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
748
415
354
44
36
31
21
17
17
12
12
9
5
5
4
3
2
2
2
Host
Mouse
679
94
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This C-JUN antibody is un-conjugated
16
16
16
12
9
9
9
7
7
7
7
7
7
7
7
Application
Western Blotting (WB)
589
350
181
100
99
84
68
62
21
20
11
11
8
6
4
3
2
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Recombinant C-terminal half of c-Jun
Clone G56-206
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Jun (JUN Antibody Abstract)
Background The cellular Jun (c-Jun) and its viral counterpart, v-Jun, are efficient transcriptional activators. Both c-Jun and v-Jun are sequence-specific DNA-binding proteins that recognize the same sequence motif, termed TRE (TPA responsive element). c-Jun does not recognize this motif unless it forms a heteromeric complex with c-fos, forming the transcription factor AP1. Jun family members JunB and JunD are 44% and 45% identical to c-Jun on the protein level, respectively. Jun family members are highly conserved between species. There is 98% amino acid identity between human and mouse c-Jun, and 45% between chicken and mouse c-Jun. There is 98% amino acid homology between human and mouse JunB, 95% between human and rat JunB, and 99.5% between mouse and rat JunB. There is 77% amino acid homology between human and mouse JunD and 71% between chicken and mouse JunD. G56-206 recognizes Jun family members including c-Jun, JunB, and JunD. A truncated recombinant protein consisting of the C-terminal half of c-Jun was used as immunogen. This region contains the c-Jun DNA binding domain. The antibody was evaluated by western blot analysis using in vitro translated c-Jun and Cos-7 monkey kidney cells transfected with recombinant c-Jun.
Molecular Weight 39 kDa, (c-Jun), 35 kDa (JunB), 40-50 kDa (JunD)
Pathways MAPK Signaling, RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes We recommend to use 1-2 µg/ml of antibody concentration for western blot application.
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-C-JUN antibody (Jun Proto-Oncogene) (C-Term) (ABIN967394) Western blot analysis of c-Jun. Lane 1, recombinant c-Jun. Lane 2, BSA (negative cont...
 image for anti-C-JUN antibody (Jun Proto-Oncogene) (C-Term) (ABIN967394) anti-Jun Proto-Oncogene (JUN) (C-Term) antibody (Image 2)
Western Blotting (WB) image for anti-C-JUN antibody (Jun Proto-Oncogene) (C-Term) (ABIN967394) anti-Jun Proto-Oncogene (JUN) (C-Term) antibody (Image 3)
Product cited in: Curran, Bravo, Müller: "Transient induction of c-fos and c-myc in an immediate consequence of growth factor stimulation." in: Cancer surveys, Vol. 4, Issue 4, pp. 655-81, 1988 (PubMed).

Angel, Karin: "The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation." in: Biochimica et biophysica acta, Vol. 1072, Issue 2-3, pp. 129-57, 1992 (PubMed).