Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody

Details for Product No. ABIN967401
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Antigen
Synonyms
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek ... show more
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek1, 2, JNKK, Jnkk2, Mapkk7, Mek7, Mkk7, JNKK1, MEK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Serk1, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, F19C24.26, F19C24_26, MAP KINASE KINASE 4, mitogen-activated protein kinase kinase 4, MKK4A-l, map2k4, zgc:136500 show less
Reactivity
Human
(276), (163), (153), (60), (52), (48), (36), (12), (2), (2), (1)
Host
Mouse
(248), (30), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Western Blotting (WB), Immunoprecipitation (IP)
(169), (112), (86), (55), (50), (44), (17), (15), (8), (7), (3), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Options
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Catalog No. ABIN967401
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Immunogen Recombinant Human JNKK
Clone G282-114
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name JNKK1
Background JNKK (JNK kinase) is a member of the mitogen-activated protein kinase (MAPK) kinase family. MAPKK family members are components of key signal transduction cascades that link events at the cell surface to responses in the nucleus. MAPK signaling cascades are found in species as varied as yeast and humans with many of the proteins being well conserved. Members of the MAPK family are activated by dual phosphorylation on threonine and tyrosine in response to a variety of extracellular stimuli. Activation of the JNK (Jun N- terminal kinase)/SAPK (stress-activated protein kinase) MAPK pathway occurs in response to factors that cause stress to the cell, and leads to Jun induced transcription. In this protein kinase cascade, MEKK (MAPK kinase kinase) phosphorylates JNKK, JNKK phosphorylates JNK, and JNK phosphorylates Jun. Phosphorylation increases the transcriptional activity of Jun. JNKK migrates at 45 kDa in SDS-PAGE. Clone G282-114 recognizes human JNKK. It may cross-react with other kinases in the MAP kinase pathway.
Molecular Weight 45 kDa
Application Notes Applications western blot analysis (1-2 µg/ml) and immunoprecipitation (1-2 µg/1x10e6 cells).
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Davis: "MAPKs: new JNK expands the group." in: Trends in biochemical sciences, Vol. 19, Issue 11, pp. 470-3, 1995 (PubMed).

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