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Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) (C-Term) antibody

Details for Product No. ABIN967455, Supplier: Log in to see
Antigen
  • AI528809
  • CD140b
  • PDGFR-1
  • Pdgfr
  • CD140B
  • IBGC4
  • JTK12
  • PDGFR
  • PDGFR1
Alternatives
anti-Human Platelet-Derived Growth Factor Receptor, beta Polypeptide antibody for Immunofluorescence
Epitope
C-Term
33
26
22
20
20
17
16
15
14
13
13
6
5
4
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
383
205
163
6
5
5
5
3
2
1
1
1
1
Host
Rabbit
309
92
19
3
3
Clonality
Polyclonal
Conjugate
Un-conjugated
15
14
12
10
10
9
9
8
7
7
7
7
7
7
3
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
241
109
99
79
74
55
51
22
11
9
4
4
4
3
3
2
2
2
1
1
1
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Human betaPDGFR (C-terminal) Recombinant Protein QC Testing: Mouse Tested in Development: Human
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The polyclonal antibody was purified from antiserum by affinity chromatography.
Alternative Name beta PDGFR (PDGFRB Antibody Abstract)
Background Platelet derived growth factor (PDGF) plays a role in regulating a number of biological processes including cellular proliferation and development through signal transduction. PDGF consists of homo- or heterodimers of two chains, A and B, which are encoded by two separate genes. The three possible combinations of the PDGF chains, AA, AB, and BB are all biologically active. The PDGF receptor (PDGFR) is a protein tyrosine kinase. Ligand binding to the PDGFR leads to tyrosine phosphorylation of numerous intracellular proteins, including the receptor itself. The PDGFR consists of two subunits, alpha and beta, which are encoded by two separate genes. The alpha subunit binds to both the A and B PDGF chains with high affinity, whereas the beta subunit binds only to the B chain with high affinity. Ligand binding results in receptor dimerization, with the PDGF type (AA, AB, or BB) influencing the resulting PDGFR subunit composition (alphaalpha, alphabeta, or betabeta). That is, PDGF-AA binds to alphaalpha receptors, PDGF-AB binds to alphaalpha and alphabeta receptors, and PDGF-BB binds to alphaalpha, alphabeta, or betabeta receptors. This polyclonal antibody has been reported to recognize both mouse and human betaPDGFR. The immature and mature forms of the betaPDGFR subunit have been reported to be observed by SDS-PAGE migrating at 160 and 180 kDa, respectively.
Synonyms: Platelet Derived Growth Factor Receptor beta subunit
Molecular Weight 160 kDa & 180 kDa
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Comment

Related Products: ABIN967390, ABIN968538

Restrictions For Research Use only
Format Liquid
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Product cited in: Bazenet, Kazlauskas: "The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP." in: Oncogene, Vol. 9, Issue 2, pp. 517-25, 1994 (PubMed).

Valius, Kazlauskas: "Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal." in: Cell, Vol. 73, Issue 2, pp. 321-34, 1993 (PubMed).

Kazlauskas, Cooper: "Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase." in: The EMBO journal, Vol. 9, Issue 10, pp. 3279-86, 1990 (PubMed).

Kazlauskas, Durden, Cooper: "Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit." in: Cell regulation, Vol. 2, Issue 6, pp. 413-25, 1991 (PubMed).

Kazlauskas, Kashishian, Cooper et al.: "GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit." in: Molecular and cellular biology, Vol. 12, Issue 6, pp. 2534-44, 1992 (PubMed).

Background publications Valius, Bazenet, Kazlauskas: "Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively." in: Molecular and cellular biology, Vol. 13, Issue 1, pp. 133-43, 1993 (PubMed).