Serotonin Receptor 2B antibody (HTR2B) (AA 1-58)

Details for Product anti-HTR2B Antibody No. ABIN967504, Supplier: Log in to see
Antigen
  • 5-HT2B
  • 5HT2B
  • 5htr2b
  • HTR2B
  • 5ht2b
  • zgc:194094
  • zgc:194119
  • AJ012488
  • AV377389
  • 5-HT(2B)
  • 5-hydroxytryptamine (serotonin) receptor 2B
  • 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • HTR2B
  • htr2b
  • LOC100228803
  • Htr2b
Alternatives
anti-Rat (Rattus) Serotonin Receptor 2B antibody for ELISA
Epitope
AA 1-58
13
12
7
6
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
116
44
35
3
2
2
2
2
1
1
Host
Mouse
114
10
Clonality (Clone)
Monoclonal ()
Conjugate
This Serotonin Receptor 2B antibody is un-conjugated
5
5
5
3
3
3
3
3
3
3
3
2
2
2
2
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
65
34
33
32
27
19
5
2
2
1
Options
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Brand BD Pharmingen™
Immunogen Human 5HT[2B]R (aa. 1-58) fusion protein
Clone A72-1
Isotype IgG1, kappa
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Serotonin Receptor 5-HT 2BR (HTR2B Antibody Abstract)
Background Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor, plays an important role in regulating diverse biological processes in the central and peripheral nervous systems, the cardiovascular system and the gastrointestinal systems. The different functions of serotonin are thought to be mediated through specific receptors. Physiological, biochemical, and pharmacological studies have defined at least fourteen serotonin receptors. The fourteen receptors are grouped in seven subtypes according to operational, structural, and transductional properties. The 5-HT2 receptors (5 -HT[2A]R, 5-HT[2B]R, an d 5-HT[2C]R) may be considered as prototypes for the study of serotonin receptors . Their functions are mediated by the second messenger inositol polyphosphate in a G-protein coupled pathway. They are expressed in diverse tissues including brain, vascular smooth muscles and platelets. The 5-HT[2A]R-mRNAs have been found in only a few areas of the brain, including the frontal cortex, piriform cortex, ventro-caudal part of CA3, motor cranial nerve nuclei in the brainstem, and the ventral horn of the spinal cord. The 5-HT[2C]R mRNA has been found at high levels in many parts of the brain including retrosplenial piriform and entorhinal cortex, anterior olfactory nucleus, substantia nigra pars compacta, several brainstem nuclei and the whole grey matter of the spinal cord. The 5-HT[2B]R was cloned in stomach fundus, where it is abundantly expressed.
Molecular Weight 45-55 kDa
Pathways JAK-STAT Signaling, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Serotonin Receptor 2B antibody (HTR2B) (AA 1-58) (ABIN967504) Immunohistochemical staining of neurons in rat brain (hippocampus) (first panel). A z...
Western Blotting (WB) image for anti-Serotonin Receptor 2B antibody (HTR2B) (AA 1-58) (ABIN967504) Western blot analysis for 5-HT2BR (second panel). A rat whole brain lysate was probed...
Immunohistochemistry (IHC) image for anti-Serotonin Receptor 2B antibody (HTR2B) (AA 1-58) (ABIN967504) anti-Serotonin Receptor 2B (HTR2B) (AA 1-58) antibody (Image 3)
Western Blotting (WB) image for anti-Serotonin Receptor 2B antibody (HTR2B) (AA 1-58) (ABIN967504) anti-Serotonin Receptor 2B (HTR2B) (AA 1-58) antibody (Image 4)
Product cited in: Duxon, Flanigan, Reavley, Baxter, Blackburn, Fone: "Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system." in: Neuroscience, Vol. 76, Issue 2, pp. 323-9, 1997 (PubMed).

Saudou, Hen: "5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates." in: Neurochemistry international, Vol. 25, Issue 6, pp. 503-32, 1995 (PubMed).

Pompeiano, Palacios, Mengod: "Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors." in: Brain research. Molecular brain research, Vol. 23, Issue 1-2, pp. 163-78, 1994 (PubMed).

Humphrey, Hartig, Hoyer: "A proposed new nomenclature for 5-HT receptors." in: Trends in pharmacological sciences, Vol. 14, Issue 6, pp. 233-6, 1993 (PubMed).

Foguet, Hoyer, Pardo, Parekh, Kluxen, Kalkman, Stühmer, Lübbert: "Cloning and functional characterization of the rat stomach fundus serotonin receptor." in: The EMBO journal, Vol. 11, Issue 9, pp. 3481-7, 1992 (PubMed).