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CrmA Or CPXV207 Protein antibody

Details for Product No. ABIN967526
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Antigen
Reactivity
Cowpox virus
Host
Mouse
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN967526
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Immunogen Coxpox CrmA (full-length) Recombinant Protein
Clone A71-1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CrmA
Background CrmA (cytokine response modifier A) is a cowpox virus-encoded serpin protein that inhibits apoptosis in a variety of systems. CrmA protects cells against apoptosis by inhibiting specific members of the ICE/CED-3 cysteine protease (designated caspase) family that are essential for apoptosis. One of the proteases inhibited by CrmA is caspase-3 (also known as CPP32, Yama, apopain). Caspase-3 is activated early in apoptosis and appears to be involved in the proteolysis of several important molecules. Activated caspase-3 is found only in cells undergoing apoptosis, and consists of 17 and 11 kDa subunits that are derived from a 32 kDa proenzyme (pro-caspase-3) by cleavage at multiple aspartic acid sites. Poly (ADP-ribose) polymerase (PARP) is a protein cleaved by activated caspase-3 during apoptosis. CrmA inhibits PARP cleavage, thereby blocking apoptosis. It is thought that if a particular apoptotic pathway can be inhibited by CrmA, then the activation of a caspase is necessary for apoptosis to take place. For example, CrmA has been shown to block Fas-mediated apoptosis, suggesting that activation of one or more caspases is required for Fas-induced cell death.
Synonyms: Cytokine Response Modifier A
Molecular Weight 38 kDa
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-CrmA Or CPXV207 Protein antibody Western blot analysis of recombinant CrmA. Lane 1: 0.5 µg of full-length recombinant CrmA was probed with the mouse anti-CrmA antibody (clone A71-1) at 1-2 µg/ml.
anti-CrmA Or CPXV207 Protein antibody (2) anti-CrmA Or CPXV207 Protein antibody (Image 2)
Product cited in: Komiyama, Quan, Salvesen: "Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA." in: Advances in experimental medicine and biology, Vol. 389, pp. 173-6, 1997 (PubMed).

Juo, Kuo, Reynolds et al.: "Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases." in: Molecular and cellular biology, Vol. 17, Issue 1, pp. 24-35, 1997 (PubMed).

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