Plasminogen (PLG) antibody

Details for Product No. ABIN967561
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Antigen
Synonyms wu:fb70e09, PLG, LPA, plg, Ab1-346, AI649309, Pg
Reactivity
Human
(265), (75), (37), (17), (13), (12), (4), (2), (2), (1), (1)
Host
Mouse
(131), (118), (43), (39), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(31), (12), (10), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP)
(203), (182), (52), (27), (27), (25), (25), (20), (15), (14), (12), (10), (10), (8), (8), (5), (5), (4), (3), (3), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN967561
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Immunogen Recombinant Human Angiostatin
Clone C9-1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Angiostatin
Background The specific events which trigger the conversion of a primary malignant tumor into a more rapidly growing invasive neoplasm are largely unknown. One of the essential parameters for metastatic growth is the vascularization of the tumor, brought about by tumor angiogenesis factors. Recently, a new factor has been identified, designated angiostatin, which has been found to be an inhibitor of angiogenisis in a Lewis lung carcinoma animal model. Angiostatin is a 38 kDa proteolytic cleavage product of plasminogen, a 93 kDa protein. This factor has been shown to inhibit in vivo metastastic growth, regress primary tumors, as well as decrease the total number of vascular endothelial cells in vitro by inhibiting proliferation of these cells. The C9-1 clone recognizes the 93 kDa human plasminogen as well as the 38 kDa angiostatin fragment in western blot analysis. A recombinant protein containing the full length human angiostatin (361 amino acids, plus His Tag) was used as the immunogen.
Molecular Weight 93 kDa (plasminogen), ~38 kDa (angiostatin)
Research Area Cancer, Angiogenesis, Cytokines
Application Notes Applications include western blot analysis (0.5-2 µg/ml) and immunoprecipitation (2 µg/ml).
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Plasminogen (PLG) antibody Western blot analysis of human Angiostatin. Lane 1, human plasma cells. Lane 2, 1.0 µg of purified recombinant Angiostatin. Clone C9-1 identified the unprocessed form of human plasminogen (93 kDa) as well as purified angiostatin (38 kDa).
anti-Plasminogen (PLG) antibody (2) anti-Plasminogen (PLG) antibody (Image 2)
Product cited in: Fidler: "Cancer metastasis." in: British medical bulletin, Vol. 47, Issue 1, pp. 157-77, 1991 (PubMed).

OReilly, Holmgren, Shing et al.: "Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma." in: Cell, Vol. 79, Issue 2, pp. 315-28, 1994 (PubMed).

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