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Ezrin (EZR) (pTyr353) antibody

Details for Product No. ABIN967575, Supplier: Login to see
Antigen
  • ezr
  • vil2
  • wu:fc05c03
  • wu:fj31d06
  • cvil
  • cvl
  • CVIL
  • CVL
  • VIL2
  • AW146364
  • R75297
  • Vil2
  • p81
  • ATVLN2
  • T11A7.16
  • T11A7_16
  • villin 2
Epitope
pTyr353
30
29
24
23
23
22
15
14
13
8
8
5
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
333
177
155
13
10
8
5
4
3
3
3
3
2
2
Host
Mouse
273
32
26
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
11
9
8
5
5
5
4
4
4
4
4
4
2
1
1
Application
Western Blotting (WB)
265
106
66
50
45
25
9
9
6
4
3
2
1
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Phosphorylated Human Ezrin Peptide
Clone I66-386
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Ezrin (EZR Antibody Abstract)
Background Ezrin is a member of the ERM (ezrin-radixin-moesin) family of proteins that function as crosslinkers between the actin cytoskeleton and the plasma membrane. Ezrin is a substrate for the tyrosine kinase epidermal (EGF) and hepatocyte growth factor (HGF) receptors. Upon EGF or HGF stimulation, ezrin is phosphorylated on tyrosine 353 (Y353), which is required for its interaction with phosphatidylinositol 3 kinase p85 subunit and activation of Akt.
The I66-386 monoclonal antibody recognizes the phosphorylated Y353 of human ezrin.
Molecular Weight 80 kDa
Research Area Cancer, Cytoskeleton, Microfilaments
Pathways
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-Ezrin (EZR) (pTyr353) antibody (ABIN967575) Western blot analysis of Ezrin (pY353). Human K562 cells were either left untreated (...
Product cited in: Gautreau, Poullet, Louvard et al.: "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 13, pp. 7300-5, 1999 (PubMed).