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C-JUN antibody (Jun Proto-Oncogene) (pSer63)

Details for Product anti-JUN Antibody No. ABIN967578, Supplier: Log in to see
Antigen
  • AP-1
  • AP1
  • B230310J22Rik
  • Bsk
  • BSK
  • BSK/DJNK
  • c-jun
  • c-Jun
  • CG2275
  • CG5680
  • cJun
  • D-JNK
  • d-JRA
  • d-jun
  • d-Jun
  • D-Jun
  • D-jun
  • D-jun/Jra
  • D-junk
  • dAP-1
  • DBSK/JNK
  • DJNK
  • dJNK
  • DJNK/bsk
  • dJRA
  • dJra
  • DJUN
  • DJun
  • djun
  • dJun
  • dJUN
  • Djun
  • dm-Jun
  • Dmel\\CG2275
  • Dmel\\CG5680
  • fj36h07
  • JNK
  • Jnk
  • jnk
  • JNK/SAPK
  • JRA
  • jra
  • jun
  • Jun
  • JUN
  • Junc
  • Junk
  • l(2)46Ef
  • l(2)IA109
  • l(2R)IA109
  • p39
  • SAPKa
  • V
  • wu:fj36h07
  • zgc:65863
Alternatives
anti-Mouse (Murine) C-JUN antibody for Western Blotting
Epitope
pSer63
71
58
41
41
40
40
40
34
23
20
19
19
13
13
13
13
12
11
8
8
8
8
8
6
6
6
5
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
748
409
348
42
36
31
21
17
17
12
12
9
5
5
4
3
2
2
2
Host
Mouse
679
94
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This C-JUN antibody is un-conjugated
17
17
17
10
10
10
7
7
7
7
7
7
7
7
7
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
587
349
186
100
98
79
75
62
21
20
11
11
8
6
4
3
2
1
Supplier
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Brand BD Pharmingen™
Clone 2-c
Isotype IgG1
Cross-Reactivity (Details) Predicted: Mouse, Rat
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name C-Jun (JUN Antibody Abstract)
Background The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation of serines 63 (S63) and 73 in its activation domain. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity.
The 2/c-Jun/(S63) monoclonal antibody recognizes the phosphorylated S63 of c-Jun.
Molecular Weight 39 kDa
Pathways MAPK Signaling, RTK Signaling, WNT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-C-JUN antibody (Jun Proto-Oncogene) (pSer63) (ABIN967578) Western blot analysis of c-Jun (pS63) in human vascular endothelium. Lysates from con...
Product cited in: Weiss, Bohmann: "Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 2, pp. 111-3, 2004

Dunn, Wiltshire, MacLaren, Gillespie: "Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor." in: Cellular signalling, Vol. 14, Issue 7, pp. 585-93, 2002

Shaulian, Karin: "AP-1 in cell proliferation and survival." in: Oncogene, Vol. 20, Issue 19, pp. 2390-400, 2001

Behrens, Sibilia, Wagner: "Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation." in: Nature genetics, Vol. 21, Issue 3, pp. 326-9, 1999

Wisdom, Johnson, Moore: "c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms." in: The EMBO journal, Vol. 18, Issue 1, pp. 188-97, 1999

Smeal, Binetruy, Mercola, Grover-Bardwick, Heidecker, Rapp, Karin: "Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73." in: Molecular and cellular biology, Vol. 12, Issue 8, pp. 3507-13, 1992

Lamph, Wamsley, Sassone-Corsi, Verma: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988