Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pThr310) antibody

Details for Product No. ABIN967581
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Antigen
Synonyms
Cas, Crkas, P130CAS, CTNND1, cas, p120, Xp120, ctnnd, p120cas, p120ctn, p120(ctn), Xp120(ctn), p120-catenin, CAS, CAS1, CASS1, CRKAS, P130Cas, AA409437, AU019353, Catns, Ctnnd, P120, mKIAA0384, CTNND, ... show more
Cas, Crkas, P130CAS, CTNND1, cas, p120, Xp120, ctnnd, p120cas, p120ctn, p120(ctn), Xp120(ctn), p120-catenin, CAS, CAS1, CASS1, CRKAS, P130Cas, AA409437, AU019353, Catns, Ctnnd, P120, mKIAA0384, CTNND, P120CAS, P120CTN, p120(CAS), p120(CTN), C12orf30, MDM20, NAP1 show less
Epitope
pThr310
(15), (11), (9), (8), (6), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(92), (39), (36), (12), (12), (12), (12)
Host
Mouse
(81), (17)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(69), (29), (28), (26), (17), (16), (15), (14), (10), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN967581
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Immunogen Phosphorylated Human p120 Catenin
Clone LPR-02
Isotype IgG1, kappa
Characteristics 1. Please refer to us for technical protocols.
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p120 Catenin
Background The membrane-associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src-transformed cells. p120 catenin is localized to the E-Cadherin/catenin cell adhesion complex. Like b- and g-catenin, p120 catenin directly associates with the cytoplasmic C terminus of E-Cadherin via its Arm domain. It exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. Phosphorylation of multiple serine (S252, S268, S288, and S879) and threonine (T310 and T916) residues in p120 catenin may regulate its activity. The S879 residue is phosphorylated after PKC activation, while the S268 site is dephosphorylated after PKC activation. The latter residue is phosphorylated in vitro by p160 Rock. S252 and T310 residues are phosphorylated in vitro by GSK3b. Thus, p120 catenin function may be regulated in a complex manner through both serine and threonine phosphorylation. The 22/p120 (pT310) monoclonal antibody recognizes the phosphorylated T310 in the regulatory domain of p120 catenin.
Molecular Weight 120 kDa
Comment

Related Products: ABIN968533, ABIN968887, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer Aqueous buffered solution.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pThr310) antibody Western blot analysis of p120 catenin (pT310) in human epidermis. Lysates from control (First Panel) and calyculin A-plus-okadaic acid-treated (Second Panel) human A-431 epidermoid carcinoma (ABIN968533 and ABIN968887, respectively) were probed with purified mouse anti-p120 catenin (pT310) monoclonal antibody at concentrations of 0.0078, 0.0039, and 0.0019 µg/ml (lanes 1, 2, and 3, respectively). p120 catenin (pT310) is identified as a band of 120 kDa in the treated cells.
Product cited in: Reynolds, Roczniak-Ferguson: "Emerging roles for p120-catenin in cell adhesion and cancer." in: Oncogene, Vol. 23, Issue 48, pp. 7947-56, 2004 (PubMed).

Xia, Brooks, Campos-González et al.: "Serine and threonine phospho-specific antibodies to p120-catenin." in: Hybridoma and hybridomics, Vol. 23, Issue 6, pp. 343-51, 2005 (PubMed).

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