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Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pThr310) antibody

Details for Product No. ABIN967581, Supplier: Log in to see
Antigen
  • Cas
  • Crkas
  • P130CAS
  • CTNND1
  • cas
  • p120
  • Xp120
  • ctnnd
  • p120cas
  • p120ctn
  • p120(ctn)
  • Xp120(ctn)
  • p120-catenin
  • CAS
  • CAS1
  • CASS1
  • CRKAS
  • P130Cas
  • AA409437
  • AU019353
  • Catns
  • Ctnnd
  • P120
  • mKIAA0384
  • CTNND
  • P120CAS
  • P120CTN
  • p120(CAS)
  • p120(CTN)
  • C12orf30
  • MDM20
  • NAP1
Alternatives
anti-Mouse (Murine) Catenin (Cadherin-Associated Protein), delta 1 antibody for ELISA
Epitope
pThr310
15
12
11
8
7
6
5
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Monkey, Mouse (Murine)
136
59
42
9
8
1
Host
Mouse
92
49
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
5
4
2
2
2
1
1
1
1
1
1
1
1
1
Application
Fluorescence Microscopy (FM), Immunoprecipitation (IP), Western Blotting (WB)
95
37
31
27
26
24
17
11
9
9
5
3
2
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Phosphorylated Human p120 Catenin
Clone 22-p120 (pT310)
Isotype IgG1, kappa
Characteristics 1. Please refer to us for technical protocols.
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p120 Catenin (CTNND1 Antibody Abstract)
Background The membrane-associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src-transformed cells. p120 catenin is localized to the E-Cadherin/catenin cell adhesion complex. Like b- and g-catenin, p120 catenin directly associates with the cytoplasmic C terminus of E-Cadherin via its Arm domain. It exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. Phosphorylation of multiple serine (S252, S268, S288, and S879) and threonine (T310 and T916) residues in p120 catenin may regulate its activity. The S879 residue is phosphorylated after PKC activation, while the S268 site is dephosphorylated after PKC activation. The latter residue is phosphorylated in vitro by p160 Rock. S252 and T310 residues are phosphorylated in vitro by GSK3b. Thus, p120 catenin function may be regulated in a complex manner through both serine and threonine phosphorylation. The 22/p120 (pT310) monoclonal antibody recognizes the phosphorylated T310 in the regulatory domain of p120 catenin.
Molecular Weight 120 kDa
Pathways EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Comment

Related Products: ABIN968533, ABIN968887, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-Catenin (Cadherin-Associated Protein), delta 1 (CTNND1) (pThr310) antibody (ABIN967581) Western blot analysis of p120 catenin (pT310) in human epidermis. Lysates from contro...
Product cited in: Xia, Brooks, Campos-González et al.: "Serine and threonine phospho-specific antibodies to p120-catenin." in: Hybridoma and hybridomics, Vol. 23, Issue 6, pp. 343-51, 2005 (PubMed).

Reynolds, Roczniak-Ferguson: "Emerging roles for p120-catenin in cell adhesion and cancer." in: Oncogene, Vol. 23, Issue 48, pp. 7947-56, 2004 (PubMed).