SNCA antibody (pTyr125, Tyr125)

Catalog No. ABIN967584

Product Details anti-SNCA Antibody

Target: SNCA (Synuclein, alpha (SNCA))

Binding Specificity: pTyr125, Tyr125

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB)

Brand: BD Pharmingen™

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of alpha-Synuclein

Clone: I57-628

Isotype: IgG2b kappa

Application Details

Comment:

Related Products: ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-SNCA antibody (ABIN967584)

Forman, Trojanowski, Lee: "Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs." in: Nature medicine, Vol. 10, Issue 10, pp. 1055-63, (2004) (PubMed).

Nakamura, Yamashita, Nagano, Takahashi, Avraham, Avraham, Matsumoto, Nakamura: "Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases." in: FEBS letters, Vol. 521, Issue 1-3, pp. 190-4, (2002) (PubMed).

Takahashi, Yamashita, Nakamura, Nagano, Nakamura: "Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress." in: Brain research, Vol. 938, Issue 1-2, pp. 73-80, (2002) (PubMed).

Ellis, Schwartzberg, Grider, Fink, Nussbaum: "alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 3879-84, (2001) (PubMed).

Nakamura, Yamashita, Takahashi, Nakamura: "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125." in: Biochemical and biophysical research communications, Vol. 280, Issue 4, pp. 1085-92, (2001) (PubMed).

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha Synuclein (SNCA Products)

Synonyms: snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody

Background: The 140-amino-acid alpha-Synuclein protein is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). This protein is expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. The Tyrosine 125 (Y125) residue of alpha-Synuclein plays an important role in stress-induced dimerization of the protein and is phosphorylated by Pyk/RAFTK via the Src-family kinases Fyn and c-Src.
The I57-628 antibody recognizes alpha-Synuclein phosphorylated at Y125.

Molecular Weight: 19 kDa

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity