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Caveolin 2 antibody (CAV2) (pTyr27)

Details for Product anti-CAV2 Antibody No. ABIN967595, Supplier: Login to see New
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Synonyms cav-2, CAV2, CAV-2, zgc:86696, wu:fc52e01, caveolin-2, Cav-2, cav, Caveolin-2, cav2, CAV, AI447843
(15), (14), (12), (7), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(77), (36), (34), (3), (2), (1), (1)
(86), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
This Caveolin 2 antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Fluorescence Microscopy (FM), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
(69), (22), (22), (12), (11), (10), (8), (6), (5), (3), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Brand BD Pharmingen™
Immunogen Phosphorylated Human Caveolin 2
Clone 40-Caveolin 2
Isotype IgG1, kappa
Characteristics 1. Please refer to us for technical protocols.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Caveolin 2 (CAV2 Antibody Abstract)
Background The caveolins are a family of transmembrane proteins that are required for the structural integrity and functions of non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. The intracellular functions of caveolae include roles in cholesterol homeostasis, signal transduction, and vesicle transport. Caveolins 1 and 2 form hetero-oligomers in the endoplasmic reticulum, Golgi complex and trans-Golgi-derived transport vesicles in most tissues. The highest levels of these complexes are found in adipocytes, fibroblasts, and endothelial, epithelial, and smooth muscle cells. Upon phosphorylation at tyrosine 19 or 27, caveolin 2 dissociates from caveolin 1, and the two phosphorylated forms of caveolin 2 localize to distinct areas of the cell. There are reports that internalization of caveolae may be regulated by tyrosine phosphorylation of caveolin 2.
The 40/Caveolin 2 monoclonal antibody recognizes the phosphorylated tyrosine 27 (pY27) of caveolin 2.
Molecular Weight 20 kdA
Research Area Cardiovascular, Atherosclerosis, Organelles
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment The antibody should be kept at -20°C for long term storage, and it may be kept at 4°C for short term storage.
Supplier Images
Western Blotting (WB) image for anti-Caveolin 2 antibody (CAV2) (pTyr27) (ABIN967595) Western blot analysis of Caveolin 2 (pY27) in human endothelial cells. Lysates from p...
 image for anti-Caveolin 2 antibody (CAV2) (pTyr27) (ABIN967595) Caveolin 2 (pY27) staining on tonsil. Fresh human tonsil was incubated in 5 mM Pervan...
Immunohistochemistry (IHC) image for anti-Caveolin 2 antibody (CAV2) (pTyr27) (ABIN967595) anti-Caveolin 2 (CAV2) (pTyr27) antibody (Image 3)
Western Blotting (WB) image for anti-Caveolin 2 antibody (CAV2) (pTyr27) (ABIN967595) anti-Caveolin 2 (CAV2) (pTyr27) antibody (Image 4)
Product cited in: Zaas, Duncan, Li et al.: "Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4864-72, 2005 (PubMed).

Wang, Lee, Capozza et al.: "Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27)." in: Biochemistry, Vol. 43, Issue 43, pp. 13694-706, 2004 (PubMed).

Williams, Lisanti: "The caveolin proteins." in: Genome biology, Vol. 5, Issue 3, pp. 214, 2004 (PubMed).

Conner, Schmid: "Regulated portals of entry into the cell." in: Nature, Vol. 422, Issue 6927, pp. 37-44, 2003 (PubMed).

Catalog No. ABIN967595
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