You are viewing an incomplete version of our website. Please click to reload the website as full version.

CrkL antibody (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like) (pTyr207)

Details for Product anti-CRKL Antibody No. ABIN967605, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms CRKL, wu:fa55g05, wu:fj60e01, zgc:63469, 1110025F07Rik, AA589403, AI325100, Crkol
(32), (18), (16), (15), (15), (13), (12), (12), (8), (7), (6), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(132), (79), (56), (2), (1), (1)
(112), (22), (17), (1)
Clonality (Clone)
Monoclonal ()
This CrkL antibody is un-conjugated
(6), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB)
(120), (66), (29), (22), (20), (20), (8), (5), (5), (3), (3), (2), (2), (1)
Pubmed 3 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Brand BD Pharmingen™
Immunogen Phosphorylated Human, Mouse, and Rat CrkL Peptide
Clone K30-391-11-30
Isotype IgG2a, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CrkL (CRKL Antibody Abstract)
Background Crk-Like (CrkL) is an adaptor protein that is preferentially expressed in hematopoietic cells and is encoded by a gene that is homologous to the viral oncogene v-crk (chicken tumor virus no. 10 regulator of kinase). Its SH2 and SH3 domains bind to a variety of effector proteins, such as paxillin, p130Cas, c-Cbl, c-Abl, and C3G. These interactions are involved in the regulation of cellular migration, adhesion, and transformation. Tyrosine 207 (Y207) of CrkL is phosphorylated in activated hematopoietic cells and in chronic myelogenous leukemia. This site may be a negative regulator of protein complex formation and biological activity. The K30-391.11.30 monoclonal antibody recognizes the phosphorylated Y207 of human CrkL.
Molecular Weight 39 kDa
Research Area Cancer, Transcription Factors
Pathways TCR Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway

Related Products: ABIN967389, ABIN968587

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-CrkL antibody (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like) (pTyr207) (ABIN967605) Western blot analysis of CrkL (pY207) in human chronic myelogenous leukemia. Lysates ...
Product cited in: Feller: "Crk family adaptors-signalling complex formation and biological roles." in: Oncogene, Vol. 20, Issue 44, pp. 6348-71, 2001 (PubMed).

Arai, Nosaka, Kohsaka et al.: "CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G." in: Blood, Vol. 93, Issue 11, pp. 3713-22, 1999 (PubMed).

Senechal, Heaney, Druker et al.: "Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells." in: Molecular and cellular biology, Vol. 18, Issue 9, pp. 5082-90, 1998 (PubMed).

Catalog No. ABIN967605
Contact our Customer Service for availability and price in your country.

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?