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V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL) (pTyr207) antibody

Antigen

V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL)
Synonyms Crkol, AA589403, AI325100, 1110025F07Rik, CRKL, MGC63469, zgc:63469, wu:fa55g05, wu:fj60e01
Binding Site
Alternatives

pTyr207
Clonality Monoclonal (K30-391-11-30)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN967605
Quantity 0.1 mg  (0.5 mg/ml)
Price Product not available in this region.
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anti-V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL) (pTyr207) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name CrkL
Immunogen Phosphorylated Human, Mouse, and Rat CrkL Peptide
Format Liquid
Isotype IgG2a, kappa
Clone K30-391-11-30
Description Crk-Like (CrkL) is an adaptor protein that is preferentially expressed in hematopoietic cells and is encoded by a gene that is homologous to the viral oncogene v-crk (chicken tumor virus no. 10 regulator of kinase). Its SH2 and SH3 domains bind to a variety of effector proteins, such as paxillin, p130Cas, c-Cbl, c-Abl, and C3G. These interactions are involved in the regulation of cellular migration, adhesion, and transformation. Tyrosine 207 (Y207) of CrkL is phosphorylated in activated hematopoietic cells and in chronic myelogenous leukemia. This site may be a negative regulator of protein complex formation and biological activity. The K30-391.11.30 monoclonal antibody recognizes the phosphorylated Y207 of human CrkL.
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Molecular Weight 39 kDa
Comments

Related Products: ABIN967389, ABIN968587

Application Details
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Concentration 0.5 mg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution.
Preservative 0.09% Sodium azide.
Storage Store undiluted at 4°C.
Research Area Cancer, Transcription Factors
Restrictions For Research Use only

Publications
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Product Senechal, Heaney, Druker et al.: "Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells." in: Molecular and cellular biology, Vol. 18, Issue 9, pp. 5082-90, 1998 (PubMed).

Arai, Nosaka, Kohsaka et al.: "CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G." in: Blood, Vol. 93, Issue 11, pp. 3713-22, 1999 (PubMed).

Feller: "Crk family adaptors-signalling complex formation and biological roles." in: Oncogene, Vol. 20, Issue 44, pp. 6348-71, 2001 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL)", type "Antibodies"
Hosts Rabbit (82), Mouse (10), Goat (7)
Reactivities Human (96), Rat (Rattus) (71), Mouse (Murine) (70), Horse (Equine) (55), Pig (Porcine) (55), Cow (Bovine) (37), Dog (Canine) (37), Sheep (Ovine) (36)
Applications Immunofluorescence (IF) (52), Western Blotting (WB) (47), ELISA (31), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), Immunohistochemistry (IHC) (14), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Immunoprecipitation (IP) (6), Flow Cytometry (FACS) (5), Immunocytochemistry (ICC) (3), Immunoelectron Microscopy (IEM) (3), Dot Blot (DB) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), Biotin (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), FITC (3), Gold (3), HRP (3), PE (3), PE,Cy3 (3), PE,Cy5 (3), PE,Cy5.5 (3), PE,Cy7 (3), Alexa Flour 488 (1)
Epitopes pTyr207 (23), pTyr244 (18), pTry207 (9), C-Term (3), AA 1-303 (2), Internal Region (2), N-Term (2), C-Term,AA 275-303 (1), Internal Region, pTry207 (1), N-Term,AA 49-79 (1)