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Mast/stem Cell Growth Factor Receptor (KIT) (pTyr568) antibody

Details for Product No. ABIN967608, Supplier: Log in to see
Antigen
  • Bs
  • CD117
  • Fdc
  • Gsfsco1
  • Gsfsco5
  • Gsfsow3
  • SCO1
  • SCO5
  • SOW3
  • Ssm
  • Tr-kit
  • W
  • c-KIT
  • C-Kit
  • PBT
  • SCFR
  • MGF
  • c-kit
Alternatives
anti-Human Mast/stem Cell Growth Factor Receptor antibody for Immunofluorescence
Epitope
pTyr568
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38
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Reactivity
Human
786
384
128
20
16
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2
1
Host
Mouse
619
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Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
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Application
Western Blotting (WB)
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174
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30
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Supplier
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Brand BD Pharmingen™
Immunogen Human c-kit (pY568/pY570) peptide
Clone K39-686
Isotype IgG1, kappa
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD117 (KIT Antibody Abstract)
Background CD117 (also known as c-kit) is a transmembrane tyrosine kinase receptor that binds stem cell factor (SCF, also known as kit ligand, mast cell growth factor, and steel factor) and is involved in the regulation of a wide range of tissues at various developmental stages. CD117 has been reported to play major roles in the regulation of hematopoiesis and germ cell proliferation and survival. Mutations of c-kit are associated with a wide variety of cancers and developmental diseases. Upon activation by its ligand, CD117 (c-kit) has been reported to dimerize and autophosphorylate at multiple cytoplasmic sites, which bind to downstream signal transduction molecules. Specifically, the phosphorylated tyrosines 568 and 570 (pY568/pY570) in the juxtamembrane domain of c-kit bind to several signaling molecules, including the adapter proteins SHC and APS, the tyrosine kinases Lyn, Fyn, and CHK, and the protein tyrosine phosphatase SHP-2, all of which may interact to regulate SCF signaling. The K39-686 clone has been reported to recognize the phosphorylated pY568/pY570 of human c-kit. The orthologous phosphorylation sites in mouse c-kit are pY567 and pY569. This antibody is routinely tested by western blot analysis.
Synonyms: c-kit
Molecular Weight 145 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4° C.
Supplier Images
Western Blotting (WB) image for anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr568) antibody (ABIN967608) Western blot analysis of CD117 (pY568/pY570) in human erythroleukemia cells. Lysates ...
Product cited in: Rönnstrand: "Signal transduction via the stem cell factor receptor/c-Kit." in: Cellular and molecular life sciences : CMLS, Vol. 61, Issue 19-20, pp. 2535-48, 2004 (PubMed).

Price, Rivnay, Fu et al.: "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes." in: The Journal of biological chemistry, Vol. 272, Issue 9, pp. 5915-20, 1997 (PubMed).