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Noggin (NOG) antibody

Details for Product No. ABIN967662, Supplier: Log in to see
Antigen
  • nog-A
  • nog1
  • noggin
  • noggin-1
  • SYM1
  • SYNS1
Reactivity
Human
106
39
36
7
6
6
2
1
Host
Mouse
117
26
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
14
11
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
110
67
25
20
19
11
11
11
2
1
1
1
Supplier
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Brand BD Pharmingen™
Immunogen Human Noggin Recombinant Protein
Clone L98-788
Isotype IgG1, kappa
Characteristics 1. Please refer to us for technical protocols.
2. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Noggin (NOG Antibody Abstract)
Background The L98-788 monoclonal antibody reacts with noggin glycoprotein, a secreted antagonist of the bone morphogenic proteins (BMPs). Noggin homodimers block the binding of BMPs to their receptors. The phenotypes of natural noggin mutations in humans (such as symphalangism proximal syndrome, synostoses syndrome 1, and brachydactyly type B2) and noggin-null mice indicate that noggin regulates cartilage and joint formation. Noggin is also involved in neural tube, somite, and myocardial morphogenesis and osteoblastic/osteoclastic responses to metastatic cancers. Noggin is highly conserved in vertebrates, the amino-acid sequence identities of human noggin with mouse, rat, bovine, equine, chicken, and frog (Xenopus) noggin are 99%, 99%, 98%, 97%, 89%, and 81%, respectively.
Molecular Weight 32 kDa
Research Area Embryogenesis, Lineage Markers
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Supplier Images
Western Blotting (WB) image for anti-Noggin (NOG) antibody (ABIN967662) Western Blot analysis of Noggin in human embryonic cells. Lysates from H9 human ES ce...
Western Blotting (WB) image for anti-Noggin (NOG) antibody (ABIN967662) Western Blot validation of Noggin by RNAi in transformed human epithelial cells. Lysa...
Western Blotting (WB) image for anti-Noggin (NOG) antibody (ABIN967662) Western Blot analysis of Noggin in human neuroectodermal tumor. Lysate from PFSK-1 ce...
Western Blotting (WB) image for anti-Noggin (NOG) antibody (ABIN967662) anti-Noggin (NOG) antibody (Image 4)
Product cited in: Choi, Stottmann, Yang, Meyers, Klingensmith: "The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis." in: Circulation research, Vol. 100, Issue 2, pp. 220-8, 2007

Schwaninger, Rentsch, Wetterwald, van der Horst, van Bezooijen, van der Pluijm, Löwik, Ackermann, Pyerin, Hamdy, Thalmann, Cecchini: "Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases." in: The American journal of pathology, Vol. 170, Issue 1, pp. 160-75, 2007

Groppe, Greenwald, Wiater, Rodriguez-Leon, Economides, Kwiatkowski, Affolter, Vale, Izpisua Belmonte, Choe: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, 2002

McMahon, Takada, Zimmerman, Fan, Harland, McMahon: "Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite." in: Genes & development, Vol. 12, Issue 10, pp. 1438-52, 1998

Valenzuela, Economides, Rojas, Lamb, Nuñez, Jones, Lp, Espinosa, Brannan, Gilbert: "Identification of mammalian noggin and its expression in the adult nervous system." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 9, pp. 6077-84, 1995