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FOXA2 antibody

FOXA2 Reactivity: Human, Mouse WB, BI, ICS Host: Mouse Monoclonal N17-280 unconjugated
Catalog No. ABIN967680
  • Target See all FOXA2 Antibodies
    FOXA2 (Forkhead Box A2 (FOXA2))
    Reactivity
    • 91
    • 26
    • 15
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Human, Mouse
    Host
    • 85
    • 7
    • 2
    Mouse
    Clonality
    • 78
    • 16
    Monoclonal
    Conjugate
    • 47
    • 7
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FOXA2 antibody is un-conjugated
    Application
    • 85
    • 50
    • 40
    • 25
    • 15
    • 14
    • 13
    • 10
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), BioImaging (BI), Intracellular Staining (ICS)
    Brand
    BD Pharmingen™
    Cross-Reactivity (Details)
    Predicted: Mouse
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Sodium azide is a reversible inhibitor of oxidative metabolism, therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. Since endotoxin may also affect the results of functional studies, we recommend the NA/LE (No Azide/Low Endotoxin) antibody format, if available, for in vitro and in vivo use.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    5. Triton is a trademark of the Dow Chemical Company.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human FoxA2 Peptide
    Clone
    N17-280
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product FOXA2 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Burtscher, Lickert: "Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo." in: Development (Cambridge, England), Vol. 136, Issue 6, pp. 1029-38, (2009) (PubMed).

    Lin, Metzakopian, Mavromatakis, Gao, Balaskas, Sasaki, Briscoe, Whitsett, Goulding, Kaestner, Ang: "Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development." in: Developmental biology, Vol. 333, Issue 2, pp. 386-96, (2009) (PubMed).

    DAmour, Agulnick, Eliazer, Kelly, Kroon, Baetge: "Efficient differentiation of human embryonic stem cells to definitive endoderm." in: Nature biotechnology, Vol. 23, Issue 12, pp. 1534-41, (2005) (PubMed).

    Thomson, Itskovitz-Eldor, Shapiro, Waknitz, Swiergiel, Marshall, Jones: "Embryonic stem cell lines derived from human blastocysts." in: Science (New York, N.Y.), Vol. 282, Issue 5391, pp. 1145-7, (1998) (PubMed).

    Monaghan, Kaestner, Grau, Schütz: "Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm." in: Development (Cambridge, England), Vol. 119, Issue 3, pp. 567-78, (1994) (PubMed).

    Clevidence, Overdier, Tao, Qian, Pani, Lai, Costa: "Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 9, pp. 3948-52, (1993) (PubMed).

    Lai, Prezioso, Tao, Chen, Darnell: "Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head." in: Genes & development, Vol. 5, Issue 3, pp. 416-27, (1991) (PubMed).

  • Target
    FOXA2 (Forkhead Box A2 (FOXA2))
    Alternative Name
    FOXA2 (FOXA2 Products)
    Synonyms
    hnf3b antibody, tcf3b antibody, hnf3beta antibody, hnf3-beta antibody, FOXA2 antibody, HNF3B antibody, TCF3B antibody, HNF-3B antibody, ax antibody, axl antibody, fkd1 antibody, ik:tdsubc_2g8 antibody, tdsubc_2g8 antibody, wu:fe05g04 antibody, xx:tdsubc_2g8 antibody, FoxA2-A antibody, FoxA2a antibody, xFD-3 antibody, xbeta-1 antibody, HNF-3b antibody, HNF3-beta antibody, HNF3beta antibody, Hnf-3b antibody, Hnf3b antibody, Tcf-3b antibody, Tcf3b antibody, HNF-3BETA antibody, forkhead box A2 antibody, forkhead box A2 L homeolog antibody, foxa2 antibody, FOXA2 antibody, foxa2.L antibody, Foxa2 antibody
    Background
    FoxA2, forkhead box A2, is a member of the forkhead class of DNA-binding proteins that regulates gene expression in the liver, pancreatic islets, adipocytes and some neural cells. This hepatocyte nuclear factor is a transcriptional activator for liver-specific genes such as alpha fetoprotein, albumin, tyrosine aminotransferase and transthyretin. FoxA2 is expressed in embryonic endoderm, the germ layer that gives rise to the digestive system, and contributes to the specification of the pancreas and the regulation of glucose homoeostasis. FoxA2 also has roles in neural development. Specifically, FoxA2 cooperates with related FoxA1 in the specification and differentiation of midbrain dopaminergic neurons in a dosage-dependent manner.
    Synonyms: Forkhead box A2, HNF3B, HNF-3B, HNF-3beta, hepatocyte nuclear factor 3beta
    Molecular Weight
    48 kDa
    Pathways
    Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process
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