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LYN antibody (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog) (AA 1-138)

Details for Product anti-LYN Antibody No. ABIN967689, Supplier: Log in to see
Antigen
  • LYN
  • lyn
  • JTK8
  • p53Lyn
  • p56Lyn
  • AA407514
  • Hck-2
  • v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  • Tyrosine-protein kinase Lyn
  • Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
  • LYN
  • lyn
  • Lyn
Alternatives
anti-Human LYN antibody for Immunocytochemistry
Epitope
AA 1-138
37
19
15
13
10
9
7
6
6
6
5
5
5
4
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
206
136
105
17
14
7
5
4
3
2
2
1
1
1
1
Host
Mouse
150
56
17
3
Clonality (Clone)
Monoclonal ()
Conjugate
This LYN antibody is un-conjugated
9
7
6
6
5
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
194
90
71
36
28
24
22
14
7
4
4
3
1
Options
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Immunogen Human Lyn
Clone BF12
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
No Cross-Reactivity Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Lyn (LYN Antibody Abstract)
Background Lyn is a 56 kDa cytosolic tyrosine kinase that belongs to the Src family of kinases. In addition to Src, this family includes lck, Fgr, Hck, Blk, Yes, fyn, and Yrk kinases. The lyn gene was isolated from a human placenta cDNA library and later found in a variety of cell types. Similar to other members of the Src family of tyrosine kinases, Lyn has been implicated in the regulation of cell signaling mechanisms. Lyn's function has primarily been studied in hematopoietic cells where it is associated with the high-affinity IgE receptor in basophils. It also associates with p120 Ras-GAP in thrombin-stimulated platelets. This association corresponds to an increase in Lyn kinase activity. Lyn is often observed as a doublet of about 56 kDa and 53 kDa. These forms may represent alternative splicing products of lyn mRNA.
Molecular Weight 56 kDa
Research Area Signaling, Tyrosine Kinases
Pathways Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-LYN antibody (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog) (AA 1-138) (ABIN967689) Western blot analysis of Lyn on HEL (human erythroleukemia cell line) lysate. Lane 1:...
Immunofluorescence (IF) image for anti-LYN antibody (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog) (AA 1-138) (ABIN967689) Immunofluoresent staining on Human Fibroblasts.
 image for anti-LYN antibody (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog) (AA 1-138) (ABIN967689) anti-V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN) (AA 1-138) antibody (Image 3)
Product cited in: Liang, Wisniewski, Strife, Shivakrupa, Clarkson, Resh: "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13732-8, 2002 (PubMed).

Deehan, Harnett, Harnett: "A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology 2 dom" in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 12, pp. 7462-8, 2001 (PubMed).

Müller, Jung, Wied, Welte, Jordan, Frick: "Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4553-67, 2001 (PubMed).

Liu, Oh, Horner, Rogers, Schnitzer: "Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains." in: The Journal of biological chemistry, Vol. 272, Issue 11, pp. 7211-22, 1997 (PubMed).

Bolen, Rowley, Spana, Tsygankov: "The Src family of tyrosine protein kinases in hemopoietic signal transduction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 6, Issue 15, pp. 3403-9, 1993 (PubMed).