EGFR antibody (Epidermal Growth Factor Receptor) (AA 1020-1046)

Details for Product anti-EGFR Antibody No. ABIN967697, Supplier: Log in to see
Antigen
  • C-erb
  • CG10079
  • D-EGFR
  • D-Egf
  • DEGFR
  • DER
  • DER flb
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DEgfr
  • Degfr
  • Der
  • DmHD-33
  • Dmel\\CG10079
  • EFG-R
  • EGF-R
  • EGFR
  • EGFr
  • EGfr
  • EK2-6
  • Egf
  • Egf-r
  • EgfR
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • HD-33
  • TOP
  • Torpedo/DER
  • Torpedo/Egfr
  • c-erbB
  • d-egf-r
  • dEGFR
  • dEGFR1
  • dEgfr
  • der
  • egfr
  • flb
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57EFa
  • l(2)57Ea
  • mor1
  • top
  • top/DER
  • top/flb
  • torpedo/Egfr
  • torpedo/egfr
  • EGFR12
  • EGFR15
  • egfr1
  • Erbb2
  • ERBB
  • ERBB1
  • HER1
  • PIG61
  • mENA
  • ErbB-1
  • Errp
  • 9030024J15Rik
  • AI552599
  • Erbb
  • Errb1
  • Wa5
  • wa-2
  • wa2
  • epidermal growth factor receptor
  • Epidermal growth factor receptor
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • EGFR
  • Egfr
  • egfra
  • egfr1
  • AaeL_AAEL004319
  • LOC100008806
Alternatives
anti-Human EGFR antibody for Western Blotting
Epitope
AA 1020-1046
147
138
64
64
60
58
57
54
54
53
49
49
43
38
36
33
30
30
29
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23
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9
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3
3
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2
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2
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
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1
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1
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1
1
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1
1
1
1
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1
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1
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Reactivity
Human, Mouse (Murine)
2416
864
699
29
24
18
17
15
15
6
3
2
2
2
1
1
1
Host
Mouse
1458
856
81
44
9
3
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This EGFR antibody is un-conjugated
102
80
71
63
56
54
32
32
28
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28
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28
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27
26
26
25
25
24
24
21
21
21
21
21
20
19
18
2
2
2
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
1444
677
615
555
507
272
259
228
124
84
66
56
40
24
19
14
12
11
7
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Human EGF Receptor aa. 1020-1046
Clone 13-EGFR
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name EGF Receptor (EGFR Antibody Abstract)
Background Epidermal Growth Factor (EGF) elicits a variety of cellular responses that are initiated by EGF receptor (EGF-R) binding and activation of intrinsic tyrosine kinase activity. Following ligand binding, EGF receptor is autophosphorylated and, in turn, phosphorylates several other endogenous proteins including phospholipase Cgamma. These events initiate a number of intracellular responses that include increased levels of intracellular Ca2+ and transient expression of the nuclear oncogene products c-Myc and c-Fos. This antibody is routinely tested by western blot analysis.
Molecular Weight 180 kDa
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Epidermal Growth Factor Receptor (EGFR) (AA 1020-1046) antibody (ABIN967697) Western blot analysis of EFG-R on A431 cell lysate. Lane 1 1: 2500, lane 2: 1: 5000, ...
 image for anti-Epidermal Growth Factor Receptor (EGFR) (AA 1020-1046) antibody (ABIN967697) Immunofluroescent staining on A431 cells.
 image for anti-Epidermal Growth Factor Receptor (EGFR) (AA 1020-1046) antibody (ABIN967697) anti-Epidermal Growth Factor Receptor (EGFR) (AA 1020-1046) antibody (Image 3)
Western Blotting (WB) image for anti-Epidermal Growth Factor Receptor (EGFR) (AA 1020-1046) antibody (ABIN967697) anti-Epidermal Growth Factor Receptor (EGFR) (AA 1020-1046) antibody (Image 4)
Product cited in: Deugnier, Faraldo, Janji, Rousselle, Thiery, Glukhova: "EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties." in: The Journal of cell biology, Vol. 159, Issue 3, pp. 453-63, 2002 (PubMed).

Golubovskaya, Beviglia, Xu, Earp, Craven, Cance: "Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38978-87, 2002 (PubMed).

Ford, Valle, Soroka, Merchant: "EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures." in: The Journal of clinical investigation, Vol. 99, Issue 11, pp. 2762-71, 1997 (PubMed).

Kizaka-Kondoh, Matsuda, Okayama: "CrkII signals from epidermal growth factor receptor to Ras." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 22, pp. 12177-82, 1996 (PubMed).

Ward, Gough, Rashke, Wan, Tribbick, Wang: "Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor." in: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5603-9, 1996 (PubMed).

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