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Mitogen-Activated Protein Kinase 3 (MAPK3) (AA 325-345) antibody

Details for Product No. ABIN967700
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Antigen
Synonyms
Tb08.10J17.940, ERK1, ERT2, Erk-1, Esrk1, MAPK1, MNK1, Prkm3, p44, p44erk1, p44mapk, ERK-1, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, Erk1, Ert2, Mnk1, Mtap2k, fi06b09, wu:fi06b ... show more
Tb08.10J17.940, ERK1, ERT2, Erk-1, Esrk1, MAPK1, MNK1, Prkm3, p44, p44erk1, p44mapk, ERK-1, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, Erk1, Ert2, Mnk1, Mtap2k, fi06b09, wu:fi06b09, zERK1, ATMAPK3, ATMPK3, T6D9.4, mitogen-activated protein kinase 3 show less
Epitope
AA 325-345
(47), (39), (38), (19), (17), (16), (16), (12), (12), (7), (7), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(282), (153), (147), (42), (41), (38), (37), (13), (10), (6), (3), (3), (2), (2), (2)
Host
Mouse
(238), (72), (9), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (11), (11), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(238), (104), (79), (59), (49), (46), (41), (25), (9), (8), (4), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN967700
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Immunogen Rat ERK1
Clone MK12
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human, Chicken, Dog (Canine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name ERK1
Background The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) is activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 is a 44 kDa member of the ERK family and shares 85% homology with ERK2 (42 kDa).
Molecular Weight 44 kDa
Research Area Stem Cells, Alzheimer's Disease, Signaling, Inflammation
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Mitogen-Activated Protein Kinase 3 (MAPK3) (AA 325-345) antibody Immunohistochemical staining of ERK1 in pyrimidal cells from the rat cortex: formalin-fixed paraffin-embedded tissue, with citrate pre-treatment (40X magnification).
anti-Mitogen-Activated Protein Kinase 3 (MAPK3) (AA 325-345) antibody (2) Western blot analysis of ERK1 on a rat cerebrum lysate. Lane 1: 1:4000, lane 2: 1:8000, lane 3: 1:16,000 dilution of the mouse anti-ERK1 antibody. ERK1 is expected to appear at 44 kD with crossreactivity reported to ERK2 which may appear at 42 kD.
anti-Mitogen-Activated Protein Kinase 3 (MAPK3) (AA 325-345) antibody (3) Immunofluorescence staining of human fibroblasts.
Product cited in: Reszka, Seger, Diltz et al.: "Association of mitogen-activated protein kinase with the microtubule cytoskeleton." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8881-5, 1995 (PubMed).

Wan, Huang: "Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells." in: The Journal of biological chemistry, Vol. 273, Issue 23, pp. 14533-7, 1998 (PubMed).

Ackerley, Grierson, Brownlees et al.: "Glutamate slows axonal transport of neurofilaments in transfected neurons." in: The Journal of cell biology, Vol. 150, Issue 1, pp. 165-76, 2000 (PubMed).

Aguirre-Ghiso, Liu, Mignatti et al.: "Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo." in: Molecular biology of the cell, Vol. 12, Issue 4, pp. 863-79, 2001 (PubMed).

Nowak: "Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cells." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 43377-88, 2002 (PubMed).

Validation Images
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