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Details for Product No. ABIN967718

Gap Junction Protein, alpha 1, 43kDa (GJA1) (AA 252-270) antibody

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Antigen
Synonyms AVSD3, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD, connexin 43, connexin43, gja1-A, Cx43, Npm1, Cnx43, Gja-1, AU042049, AW546267, Cx43alpha1, gja1, cx43a1, zfCx43.3, cx43, gjal, oddd, dfnb38
Epitope
»Alternatives AA 252-270
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN967718
Quantity 150 µg
Price
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Immunogen Rat Connexin-43
Clone 2
Isotype IgG1
Cross-Reactivity Chicken, Dog (Canine), Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Connexin-43
Background Gap junctions are intercellular protein pores. They enable cell-to-cell communication by allowing passage of ions and other small molecules. The subunits of gap junction channels are assembled from a family of proteins called connexins. Individual connexin molecules join to make hexameric hemichannels termed connexons, these structures dock to connexons on neighboring cells, forming gap junction pores. Connexin-43 is a member of the connexin family possessing four transmembrane regions, with cytoplasmic amino and carboxyl terminals. It undergoes rapid turnover in the cell and its monomers may reside in the ER/Golgi network, forming a reservoir available for assembly upon degradation of existing connexin-43 channels. In addition, it is believed that phosphorylation of connexin-43 plays a regulatory role both in the assembly of connexons and in gating activity at the gap junction. This antibody is routinely tested by western blot analysis.
Molecular Weight 43 kDa
Research Area Extracellular Matrix, Cytoskeleton, Signaling
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Loo, Berestecky, Kanemitsu et al.: "pp60src-mediated phosphorylation of connexin 43, a gap junction protein." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12751-61, 1995 (PubMed).

Laird, Castillo, Kasprzak: "Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells." in: The Journal of cell biology, Vol. 131, Issue 5, pp. 1193-203, 1996 (PubMed).

Lucke, Choudhry, Thom et al.: "Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium." in: The Journal of investigative dermatology, Vol. 112, Issue 3, pp. 354-61, 1999 (PubMed).

Toyofuku, Akamatsu, Zhang et al.: "c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes." in: The Journal of biological chemistry, Vol. 276, Issue 3, pp. 1780-8, 2001 (PubMed).

Giepmans, Hengeveld, Postma et al.: "Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 8544-9, 2001 (PubMed).

Alternatives for antigen "Gap Junction Protein, alpha 1, 43kDa (GJA1)", type "Antibodies"
Hosts (188), (12), (10)
Reactivities (181), (127), (114), (49), (45), (27), (20), (10), (9), (9), (8), (7), (6), (6), (5), (5), (5), (5), (4), (3), (2), (2), (1), (1)
Applications (145), (62), (58), (51), (30), (28), (11), (7), (5), (2), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (31), (26), (17), (8), (6), (6), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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