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FGF2 antibody (Fibroblast Growth Factor 2 (Basic)) (AA 1-155)

Details for Product anti-FGF2 Antibody No. ABIN967725, Supplier: Log in to see
Antigen
  • bFGF
  • BFGF
  • Fgf-2
  • FGF-2
  • Fgfb
  • FGFB
  • HBGF-2
Alternatives
anti-Human FGF2 antibody for Functional Studies
Epitope
AA 1-155
15
14
13
12
10
8
8
6
4
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
312
56
43
38
23
17
4
2
1
1
1
1
Host
Mouse
187
151
8
6
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This FGF2 antibody is un-conjugated
34
18
13
8
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
252
214
97
59
35
27
19
19
18
17
12
12
11
7
7
3
2
2
1
1
1
1
1
1
1
1
1
Supplier
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Immunogen Human bFGF aa. 1-155
Clone 6-basic FGF
Isotype IgG2a
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name basic FGF (FGF2 Antibody Abstract)
Background Basic Fibroblast Growth Factor (bFGF) is a family member of the cell-differentiating and growth promoting factors. Basic FGF exists as multiple isoforms ranging from 18-24kDa that are derived from a single mRNA species under unique translational conditions. The 18kDa isoform is primarily cytosolic, but is also secreted and may form reservoirs of bFGF in the extracellular matrix. In contrast, the larger isoforms are predominantly nuclear. At the cellular level, bFGF is a potent mitogen and promotes cell survival by inhibiting apoptosis. At the tissue level, it is involved in wound repair and induces angiogenesis. In addition, bFGF is a significant target in cancer research because it is over-expressed in some cancers and may enhance a tumor's metastatic potential.
Molecular Weight 18-24 kDa
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-FGF2 antibody (Fibroblast Growth Factor 2 (Basic)) (AA 1-155) (ABIN967725) Western blot analysis for basic FGF on a HeLa cell lysate (Human cervical epitheloid ...
 image for anti-FGF2 antibody (Fibroblast Growth Factor 2 (Basic)) (AA 1-155) (ABIN967725) Immnuofluroescence staining of human fibroblasts.
Product cited in: Yaccoby, Johnson, Mahaffey, Wezeman, Barlogie, Epstein: "Antimyeloma efficacy of thalidomide in the SCID-hu model." in: Blood, Vol. 100, Issue 12, pp. 4162-8, 2002 (PubMed).

Peng, Moffett, Myers, Fang, Stachowiak, Maher, Kratz, Hines, Fluharty, Mizukoshi, Bloom, Stachowiak: "Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors." in: Molecular biology of the cell, Vol. 12, Issue 2, pp. 449-62, 2001 (PubMed).

Estival, Monzat, Miquel, Gaubert, Hollande, Korc, Vaysse, Clemente: "Differential regulation of fibroblast growth factor (FGF) receptor-1 mRNA and protein by two molecular forms of basic FGF. Modulation of FGFR-1 mRNA stability." in: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5663-70, 1996 (PubMed).

Fox, Shanley: "Antisense inhibition of basic fibroblast growth factor induces apoptosis in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 271, Issue 21, pp. 12578-84, 1996 (PubMed).

Stachowiak, Moffett, Joy, Puchacz, Florkiewicz, Stachowiak: "Regulation of bFGF gene expression and subcellular distribution of bFGF protein in adrenal medullary cells." in: The Journal of cell biology, Vol. 127, Issue 1, pp. 203-23, 1994 (PubMed).