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TRKB antibody (AA 156-322)

NTRK2 Reactivity: Rat WB, IHC, IP, FM, BI Host: Mouse Monoclonal 47-TrkB unconjugated
Catalog No. ABIN967746
  • Target See all TRKB (NTRK2) Antibodies
    TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
    Binding Specificity
    • 16
    • 15
    • 12
    • 12
    • 10
    • 10
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 156-322
    Reactivity
    • 135
    • 90
    • 87
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 140
    • 7
    • 4
    • 1
    • 1
    Mouse
    Clonality
    • 132
    • 21
    Monoclonal
    Conjugate
    • 84
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This TRKB antibody is un-conjugated
    Application
    • 109
    • 53
    • 50
    • 21
    • 19
    • 18
    • 15
    • 14
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM), BioImaging (BI)
    Cross-Reactivity
    Rat (Rattus), Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human TrkB aa. 156-322
    Clone
    47-TrkB
    Isotype
    IgG1
    Top Product
    Discover our top product NTRK2 Primary Antibody
  • Comment

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Du, Feng, Yang, Lu: "Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1423-34, (2000) (PubMed).

    Muller, Djebbara-Hannas, Jourdain, Vutskits, Durbec, Rougon, Kiss: "Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 8, pp. 4315-20, (2000) (PubMed).

    Jovanovic, Czernik, Fienberg, Greengard, Sihra: "Synapsins as mediators of BDNF-enhanced neurotransmitter release." in: Nature neuroscience, Vol. 3, Issue 4, pp. 323-9, (2000) (PubMed).

    Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, (1999) (PubMed).

    Armanini, McMahon, Sutherland, Shelton, Phillips: "Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS." in: The European journal of neuroscience, Vol. 7, Issue 6, pp. 1403-9, (1995) (PubMed).

    Ebendal: "Function and evolution in the NGF family and its receptors." in: Journal of neuroscience research, Vol. 32, Issue 4, pp. 461-70, (1992) (PubMed).

    Klein, Conway, Parada, Barbacid: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, (1990) (PubMed).

  • Target
    TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
    Alternative Name
    TrkB (NTRK2 Products)
    Synonyms
    trkb antibody, trkb-b antibody, xtrkb antibody, si:ch211-220b11.1 antibody, trkB2 antibody, NTRK2 antibody, ntrk2 antibody, gp145-trkb antibody, TRKB antibody, GP145-TrkB antibody, trk-B antibody, AI848316 antibody, C030027L06Rik antibody, Tkrb antibody, trkB antibody, RATTRKB1 antibody, TRKB1 antibody, Trk-B antibody, TrkB antibody, neurotrophic receptor tyrosine kinase 2 antibody, neurotrophic receptor tyrosine kinase 2 L homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2b antibody, neurotrophic receptor tyrosine kinase 2 S homeolog antibody, neurotrophic tyrosine kinase, receptor, type 2 antibody, NTRK2 antibody, ntrk2.L antibody, ntrk2b antibody, ntrk2.S antibody, ntrk2 antibody, Ntrk2 antibody
    Background
    The full-length TrkB gene has been reported to encode for a 145 kDa glycosylated transmembrane tyrosine kinase and neurotrophin receptor. The same gene also has been reported to encode for a 95 kDa glycoprotein that is identical to gp145 [TrkB] at the extracellular domain and transmembrane portion but lacks the intracellular portion. TrkB has been observable in a range of 116-145 kD and 70-95 kD due to various TrkB maturation states, subcellular localizations, and glycosylation states. TrkB belongs to a family of tyrosine kinases that include the TrkA proto-oncogene and TrkC. All have an extracellular ligand-binding domain, a transmembrane region, and intracellular kinase and autophosphorylation domains. TrkB binds the neurotrophins NT3 and NT4/5, as well as brain-derived neurotrophic factor (BDNF), a peptide that helps motor neuron survival and repair. The TrkB tyrosine kinase is activated upon binding to BDNF resulting in autophosphorylation of residues Y670, Y674 and Y675 and the subsequent association of several intracellular proteins like PLCgamma, Shc, and PI3-Kinase. TrkB is widely expressed in cells of neuroepithelium and neural crest origin. Some of these include motor neurons, dopamine-producing neurons, and neurons which release gamma-aminobutyric acid in the substantia nigra, neocortex, and hippocampus. The two TrkB gene products are differentially expressed in regions of the adult brain.
    Synonyms: Neurotrophic Tyrosine Kinase Receptor Type 2, NTRK2
    Molecular Weight
    116-145 & 70-95 kDa
    Pathways
    RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
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