STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (AA 1-194)

Details for Product anti-STAT1 Antibody No. ABIN967760, Supplier: Log in to see
Antigen
  • IMUP
  • H2RSP
  • IMUP-1
  • IMUP-2
  • 2010005J02Rik
  • AA408197
  • DD6G4-4
  • CANDF7
  • ISGF-3
  • STAT91
  • STAT4
  • XStat1
  • STAT
  • STAT1
  • dZ182H3.3
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
  • signal transducer and activator of transcription 1, 91kDa
  • RIKEN cDNA 2200002D01 gene
  • signal transducer and activator of transcription 1
  • signal transducer and activator of transcription 4
  • STAT1
  • 2200002D01Rik
  • Stat1
  • stat1
  • stat4
Alternatives
anti-Human STAT1 antibody for BioImaging
Epitope
AA 1-194
99
78
58
27
23
21
19
16
15
15
14
13
9
6
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
605
297
241
43
27
26
26
23
18
15
14
11
9
5
4
4
3
3
2
2
2
1
1
Host
Rabbit
384
208
20
15
3
3
1
Clonality
Polyclonal
Conjugate
This STAT1 antibody is un-conjugated
18
17
15
14
14
14
7
7
6
6
6
6
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
2
2
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
528
178
162
112
98
53
52
29
21
14
10
5
5
4
2
1
1
1
Options
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Immunogen Human Stat1
Isotype Ig
Cross-Reactivity Chicken, Dog (Canine), Frog, Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from antiserum by negative adsorption and affinity chromatography.
Alternative Name Stat1 (STAT1 Antibody Abstract)
Background ISGF3 (interferon-stimulated gene factor 3) is the primary transcription activator induced by the binding of interferon to a specific cell surface receptor. Functional ISGF3 is a complex of four polypeptides of 113 kDa (Stat2), 91 kDa (Stat1alpha), 84 kDa (Stat1beta), and 48 kDa. The first three polypeptides contain both SH2 and SH3 domains in response to the binding of IFNalpha, IFNgamma, EGF, PDGF, or CSF-1 to their respective receptors, the cytoplasmic ISGF3 subunits become tyrosine-phosphorylated and are translocated to the nucleus. This results in the formation of an active complex with the 48 kDa protein. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs). Thus, growth factors and cytokines appear to activate a common signal transduction pathway which leads to the phosphorylation and subsequent nuclear translocation of a group of latent cytoplasmic transcription factors.
Molecular Weight 91/84 kDa
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (AA 1-194) (ABIN967760) Western blot analysis of Stat1 on A431 cell lysate. Lane 1: 1:1000, lane 2: 1:2000, l...
Immunofluorescence (IF) image for anti-STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa) (AA 1-194) (ABIN967760) Immunofluorescent staining of human endothelial cells.
Product cited in: Lemmink, Tuyt, Knol, Krikke, Vellenga: "Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon gamma." in: Blood, Vol. 98, Issue 13, pp. 3849-52, 2001 (PubMed).

Chang, Peng, Fu: "Interleukin-4 mediates cell growth inhibition through activation of Stat1." in: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10212-7, 2000 (PubMed).

Su, Kitagawa, Xue, Xie, Garofalo, Cho, Deng, Horton, Fu: "Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism." in: Nature, Vol. 386, Issue 6622, pp. 288-92, 1997 (PubMed).

Fu, Zhang: "Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter." in: Cell, Vol. 74, Issue 6, pp. 1135-45, 1993 (PubMed).

Fu, Schindler, Improta, Aebersold, Darnell: "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7840-3, 1992 (PubMed).