Catenin, beta (AA 571-781) antibody

Details for Product No. ABIN967785
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Antigen
Synonyms Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, CTNNB, MRD19, armadillo, CHBCAT, beta-catenin, ctnnb1
Epitope
AA 571-781
(45), (44), (40), (37), (24), (21), (15), (14), (13), (12), (11), (8), (6), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(330), (286), (282), (171), (156), (110), (4), (3), (2), (2), (1)
Host
Mouse
(319), (12), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (14), (14), (14), (14), (14), (14), (14), (14), (14), (14), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
(191), (140), (71), (71), (54), (22), (9), (8), (5), (1)
Pubmed 5 references available
Quantity 150 μg
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Catalog No. ABIN967785
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Immunogen Mouse beta-Catenin
Clone Ghr2
Isotype IgG1
Cross-Reactivity Human, Chicken, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name beta-Catenin
Background Beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the alpha- and beta-Catenins have been cloned, very little is known about their biochemical roles. However a link between beta-Catenin and colon cancer has been described. beta-Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
Molecular Weight 92 kDa
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Catenin, beta (AA 571-781) antibody Western blot analysis of beta-Catenin on HeLa cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of beta-Catenin antibody.
anti-Catenin, beta (AA 571-781) antibody (2) Immunofluorescent staining of A431 cell line with beta-Catenin antibody.
anti-Catenin, beta (AA 571-781) antibody (3) anti-Catenin, beta (AA 571-781) antibody (Image 3)
Product cited in: Ozawa, Ringwald, Kemler: "Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 11, pp. 4246-50, 1990 (PubMed).

Eger, Stockinger, Schaffhauser et al.: "Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity." in: The Journal of cell biology, Vol. 148, Issue 1, pp. 173-88, 2000 (PubMed).

Persad, Troussard, McPhee et al.: "Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation." in: The Journal of cell biology, Vol. 153, Issue 6, pp. 1161-74, 2001 (PubMed).

Tateishi, Omata, Tanaka et al.: "The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 571-9, 2001 (PubMed).

Lee, DAmour, Papkoff: "A yeast model system for functional analysis of beta-catenin signaling." in: The Journal of cell biology, Vol. 158, Issue 6, pp. 1067-78, 2002 (PubMed).

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