Tyrosine Kinase 2 (TYK2) (AA 46-258) antibody

Details for Product No. ABIN967792
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Antigen
Synonyms JTK1
Epitope
AA 46-258
(32), (14), (12), (11), (11), (6), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(137), (58), (45), (27), (15), (15), (15), (12), (1)
Host
Mouse
(110), (26)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
(93), (54), (36), (24), (21), (17), (13), (10), (7), (1)
Pubmed 5 references available
Quantity 50 μg
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Catalog No. ABIN967792
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Immunogen Human tyk2
Clone CB11
Isotype IgG2a
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Tyk2
Background Tyk2 is a widely expressed protein tyrosine kinase (PTK) of 1187 amino acids (135kDa). The N-terminal kinase-related domain of tyk2 shows 54% identity to the kinase-related domain of the JAK1 kinase. Surprisingly, the catalytic region of JAK1 shares more sequence identity to tyk2 than it does with JAK2 kinase. The similarity of structure between tyk2 and JAK1 suggests that both may be involved in related phosphorylation cascades. Tyk2 plays a critical role in the interferon (IFN)-alpha/beta response while JAK1 shows involvement in both the IFN-alpha/beta and IFN-gamma signal transduction pathways. JAK2, however, appears to be required only in the IFN-gamma response. It has been suggested that a portion of the large extracatalytic domain of tyk2 could interact with components of the IFN alpha/beta receptor.
Molecular Weight 135 kDa
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Tyrosine Kinase 2 (TYK2) (AA 46-258) antibody Immunofluorescent staining of Human Fibroblast cells.
anti-Tyrosine Kinase 2 (TYK2) (AA 46-258) antibody (2) Western blot analysis of tyk2 on human endothelial cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-tyk2 antibody.
Product cited in: Velazquez, Fellous, Stark et al.: "A protein tyrosine kinase in the interferon alpha/beta signaling pathway." in: Cell, Vol. 70, Issue 2, pp. 313-22, 1992 (PubMed).

Platanias, Uddin, Yetter et al.: "The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2." in: The Journal of biological chemistry, Vol. 271, Issue 1, pp. 278-82, 1996 (PubMed).

Yan, Piazza, Krishnan et al.: "Definition of the interferon-alpha receptor-binding domain on the TYK2 kinase." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 4046-51, 1998 (PubMed).

Masuda, Matsuguchi, Yamaki et al.: "Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells." in: The Journal of biological chemistry, Vol. 275, Issue 38, pp. 29331-7, 2000 (PubMed).

Blesofsky, Mowen, Arduini et al.: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001 (PubMed).

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