PTPRZ1 antibody (AA 2098-2307)

Catalog No. ABIN967799

Product Details anti-PTPRZ1 Antibody

Target: PTPRZ1 (Protein tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1))

Binding Specificity: AA 2098-2307

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTPRZ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), BioImaging (BI)

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human RPTPbeta aa. 2098-2307

Clone: 12-RPTPb

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968537, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-PTPRZ1 antibody (ABIN967799)

Padilla, Wada, Yahiro, Kimura, Niidome, Aoyagi, Kumatori, Anami, Hayashi, Fujisawa, Saito, Moss, Hirayama: "Morphologic differentiation of HL-60 cells is associated with appearance of RPTPbeta and induction of Helicobacter pylori VacA sensitivity." in: The Journal of biological chemistry, Vol. 275, Issue 20, pp. 15200-6, (2000) (PubMed).

Ratcliffe, Qu, McCormick, Tibbs, Dixon, Scheuer, Catterall: "A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta." in: Nature neuroscience, Vol. 3, Issue 5, pp. 437-44, (2000) (PubMed).

Maeda, Noda: "Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration." in: The Journal of cell biology, Vol. 142, Issue 1, pp. 203-16, (1998) (PubMed).

Levy, Canoll, Silvennoinen, Barnea, Morse, Honegger, Huang, Cannizzaro, Park, Druck: "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system." in: The Journal of biological chemistry, Vol. 268, Issue 14, pp. 10573-81, (1993) (PubMed).

Krueger, Saito: "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7417-21, (1992) (PubMed).

Target Details for PTPRZ1

Target: PTPRZ1 (Protein tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1))

Alternative Name: RPTP beta (PTPRZ1 Products)

Synonyms: HPTPZ antibody, HPTPzeta antibody, PTP-ZETA antibody, PTP18 antibody, PTPRZ antibody, PTPZ antibody, R-PTP-zeta-2 antibody, RPTPB antibody, RPTPbeta antibody, phosphacan antibody, Ptpz antibody, AI850339 antibody, DSD-1-PG antibody, PTPbeta antibody, PTPzeta antibody, Ptprz antibody, RPTPz antibody, Rptpbeta antibody, protein tyrosine phosphatase, receptor type Z1 antibody, protein tyrosine phosphatase, receptor type Z, polypeptide 1 antibody, PTPRZ1 antibody, Ptprz1 antibody

Background: Receptor-type protein-tyrosine phosphatase beta (RPTPbeta or PTPzeta) is the first mammalian tyrosine phosphatase to be characterized whose expression is limited to the nervous system. RPTPbeta consists of a large extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic domains. Three forms of RPTPbeta exist which appear to be derived from alternative splicing. The 9.5 kb and 6.4 kb transcripts encode two transmembrane forms. The 8.5 kb transcript encodes a secreted form of the extracellular domain of RPTPbeta. A region of 266 amino acids in the extracellular domain shows a high degree of homology with carbonic anhydrase. This region is very similar to rat brain chondroitin sulfate proteoglycan (3F8 PG) which appears to be the rat homologue of the entire extracellular domain of human RPTPbeta. The apparent molecular weight of human RPTPbeta is 250 kDa and approaches 300 kDa when the protein is glycosylated. This antibody was generated against a region known to have a high degree of homology to other proteoglycans, such as RPTPgamma (75% homology). This antibody is routinely tested by western blot analysis.
Synonyms: PTPzeta, Receptor-type Protein-Tyrosine Phosphatase beta

Molecular Weight: 250 kDa