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FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163)

Details for Product anti-FAS Antibody No. ABIN967816, Supplier: Log in to see
Antigen
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
  • Fas (TNF receptor superfamily member 6)
  • Fas (TNF receptor superfamily, member 6)
  • Fas cell surface death receptor
  • fatty acid synthase
  • Fas
  • FAS
  • Fasn
Alternatives
anti-Human FAS antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 1-163
49
29
24
18
15
15
15
15
12
11
10
9
9
9
8
7
7
6
5
5
5
5
4
4
4
4
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
636
110
98
15
11
10
5
4
3
3
3
3
1
Host
Mouse
410
296
23
5
4
3
3
Clonality (Clone)
Monoclonal ()
Conjugate
This FAS antibody is un-conjugated
72
63
50
29
15
8
7
7
5
5
5
4
4
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
331
308
207
145
111
83
60
52
50
45
23
18
12
7
7
6
5
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Options
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Immunogen Human Fas aa. 1-163
Clone 13-Fas
Isotype IgG2a, kappa
Cross-Reactivity Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD95 (FAS Antibody Abstract)
Background CD95 is a member of a family of cell surface receptors that includes tumor necrosis factor receptor (TNF-R), nerve growth factor receptor (NGF-R), CD40, CD27, CD30, and 4-1BB. Both murine and human Fas genes have been cloned and reportedly share 60% similarity in their amino acid sequences. CD95 (Fas) is a cell surface apoptosis-signaling molecule that is widely expressed in sites such as thymus, liver, heart, and ovary. Abnormalities in the Fas gene correlate with autoimmune features in mice and with unusually high levels of lymphocyte apoptosis in HIV-infected humans. Genetic studies have localized the Fas gene near the lpr (lymphoproliferation disease) locus on mouse chromosome 19 and further characterization reportedly has revealed that lpr is a mutation affecting the function of the Fas gene. This antibody is routinely tested by western blot analysis.
Synonyms: Fas, APO-1
Molecular Weight 45 kDa
Research Area Immunology, Innate Immunity, Cytokines, CD Antigens, Apoptosis/Necrosis, Death Receptors, Cancer, Growth Factors, Surface Receptors of Immune Cells
Pathways p53 Signaling, Apoptosis, TCR Signaling, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163) (ABIN967816) Western blot analysis of CD95 on a Daudi cell lysate (Human B lymphoblast, ATCC CCL-2...
 image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163) (ABIN967816) Immunohistochemical staining of a formalin-fixed rabbit liver section.
Product cited in: Rosen, Coll, Li, Filmus: "Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37273-9, 2001 (PubMed).

Zhuang, Demirs, Kochevar: "Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation." in: Oncogene, Vol. 20, Issue 46, pp. 6764-76, 2001 (PubMed).

MacLaren, Clark, Gillespie: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." in: Oncogene, Vol. 19, Issue 51, pp. 5906-18, 2000 (PubMed).

Arnold, Seifert, Asadullah, Volk: "Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7140-7, 1999 (PubMed).

Background publications Itoh, Yonehara, Ishii, Yonehara, Mizushima, Sameshima, Hase, Seto, Nagata: "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis." in: Cell, Vol. 66, Issue 2, pp. 233-43, 1991 (PubMed).