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FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163)

Details for Product anti-FAS Antibody No. ABIN967817, Supplier: Log in to see
Antigen
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
Alternatives
anti-Human FAS antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 1-163
39
34
28
23
15
13
13
13
11
10
10
9
8
7
7
6
5
5
5
5
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
629
100
80
10
7
5
4
3
3
3
2
1
1
1
Host
Mouse
417
286
11
6
4
3
3
Clonality (Clone)
Monoclonal ()
Conjugate
This FAS antibody is un-conjugated
71
62
48
30
14
7
6
6
4
4
4
4
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
335
282
198
131
103
74
61
54
46
44
23
13
12
8
7
5
4
3
3
3
3
2
2
2
1
1
1
1
Supplier
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Immunogen Human Fas aa. 1-163
Clone 13-Fas
Isotype IgG2a, kappa
Cross-Reactivity Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CD95 (FAS Antibody Abstract)
Background CD95 is a member of a family of cell surface receptors that includes tumor necrosis factor receptor (TNF-R), nerve growth factor receptor (NGF-R), CD40, CD27, CD30, and 4-1BB. Both murine and human Fas genes have been cloned and reportedly share 60% similarity in their amino acid sequences. CD95 (Fas) is a cell surface apoptosis-signaling molecule that is widely expressed in sites such as thymus, liver, heart, and ovary. Abnormalities in the Fas gene correlate with autoimmune features in mice and with unusually high levels of lymphocyte apoptosis in HIV-infected humans. Genetic studies have localized the Fas gene near the lpr (lymphoproliferation disease) locus on mouse chromosome 19 and further characterization reportedly has revealed that lpr is a mutation affecting the function of the Fas gene. This antibody is routinely tested by western blot analysis.
Synonyms: Fas, APO-1
Molecular Weight 45 kDa
Research Area Immunology, Innate Immunity, Cytokines, CD Antigens, Apoptosis/Necrosis, Death Receptors, Cancer, Growth Factors, Surface Receptors of Immune Cells
Pathways p53 Signaling, Apoptosis, TCR Signaling
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163) (ABIN967817) Western blot analysis of CD95 on a Daudi cell lysate (Human B lymphoblast, ATCC CCL-2...
 image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163) (ABIN967817) Immunohistochemical staining of a formalin-fixed rabbit liver section.
 image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163) (ABIN967817) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) (AA 1-163) antibody (Image 3)
Western Blotting (WB) image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (AA 1-163) (ABIN967817) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) (AA 1-163) antibody (Image 4)
Product cited in: Zhuang, Demirs, Kochevar: "Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation." in: Oncogene, Vol. 20, Issue 46, pp. 6764-76, 2001 (PubMed).

Rosen, Coll, Li et al.: "Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37273-9, 2001 (PubMed).

MacLaren, Clark, Gillespie: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." in: Oncogene, Vol. 19, Issue 51, pp. 5906-18, 2000 (PubMed).

Arnold, Seifert, Asadullah et al.: "Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7140-7, 1999 (PubMed).

Itoh, Yonehara, Ishii et al.: "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis." in: Cell, Vol. 66, Issue 2, pp. 233-43, 1991 (PubMed).