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Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 368-604) antibody (Biotin)

Details for Product No. ABIN967824
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Antigen
Synonyms COX-2, cox-2, cox2, gripghs, pgg/hs, pghs-2, phs-2, PTGS2, hcox-2, COII, COX2, Cox-2, PGHS-2, PHS-2, Pghs2, TIS10, Cox2, GRIPGHS, PGG/HS, hCox-2, PGHS2, CEF147, PHSII
Epitope
AA 368-604
(54), (11), (7), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(132), (59), (43), (18), (14), (14), (5), (2), (1)
Host
Mouse
(113), (41), (13)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(8), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(113), (68), (55), (28), (18), (16), (14), (14), (10), (9), (4), (3), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN967824
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Immunogen Rat Cox-2
Clone 4C6-1
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human, Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Cox-2
Background Cyclooxygenase (Cox) is also known as prostaglandin H synthase or PGH synthase (E.C. 1.14.99.1). It catalyzes the conversion of arachidonate to prostaglandin H2 (PGH2), the precursor of PGE2, PGF2alpha, PGD2, prostacyclin, and thromboxane A2. Cox actually has two different enzymatic activities: a cyclooxygenase that mediates the formation of PGG2 from oxygen and arachidonate and a hydroperoxidase that catalyzes a reduction of PGG2 yielding PGH2. Two Cox genes, Cox-1 and Cox-2, have been isolated in several species. A 4kb mRNA encodes the 604 amino acid Cox-2 protein. The two human Cox isoenzymes are 61% identical in amino acid composition with the active sites being highly conserved. Cox-2 mRNA and protein levels are induced by serum, lipopolysaccharides, growth factors, human chorionic gonadotropin and phorbol testers in various mammalian cell types. It has been shown that interleukin-1alpha (IL-1alpha) induces increased levels of Cox-2 mRNA and protein in human endothelial cells. The sustained increase in Cox-2 is apparently due (at least in part) to IL-1alpha increasing the stability of Cox-2 mRNA. This type of regulatory mechanism may play an important role in chronic inflammatory conditions.
Synonyms: PGHS-2, Cyclooxygenase-2
Molecular Weight 70 kDa
Comment

Related Products: ABIN968550, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 368-604) antibody (Biotin) Western blot analysis of Cox-2 on lysate from mouse macrophages treated with IFNgamma and LPS. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-Cox-2.
Product cited in: Xie, Cho, Calaycay et al.: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." in: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, 1992 (PubMed).

Hla, Neilson: "Human cyclooxygenase-2 cDNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7384-8, 1992 (PubMed).

Vane, Mitchell, Appleton et al.: "Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 6, pp. 2046-50, 1994 (PubMed).

Pritchard, OBanion, Miano et al.: "Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo." in: The Journal of biological chemistry, Vol. 269, Issue 11, pp. 8504-9, 1994 (PubMed).

Marcheselli, Bazan: "Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist." in: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24794-9, 1996 (PubMed).

Validation Images
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