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BCL2L1 antibody (BCL2-Like 1) (AA 18-233)

Details for Product anti-BCL2L1 Antibody No. ABIN967829, Supplier: Log in to see
Antigen
  • bcl-XL
  • bcl-x
  • bcl-x(l)
  • bcl-xl/s
  • bcl-xs
  • bcl2l
  • bclx
  • bclxl
  • xR11
  • BCL2L1
  • Bcl-xS
  • BCL-XL/S
  • BCL2L
  • BCLX
  • BCLXL
  • BCLXS
  • Bcl-X
  • PPP1R52
  • bcl-xL
  • bcl-xS
  • Bcl(X)L
  • Bcl-XL
  • Bcl-Xs
  • Bcl2l
  • BclX
  • Bcl-xl
  • Bclx
  • bcl-X
  • BCL-XL
  • Bcl-xL
  • bcl-xl
Alternatives
anti-Rat (Rattus) BCL2L1 antibody for Immunoprecipitation
Epitope
AA 18-233
37
26
25
22
19
13
13
13
12
11
10
7
7
7
5
5
5
5
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
337
171
147
22
10
8
6
5
3
2
2
1
Host
Rabbit
258
112
3
3
Clonality
Polyclonal
Conjugate
This BCL2L1 antibody is un-conjugated
18
13
5
4
4
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
266
142
91
76
69
51
49
25
21
14
7
4
3
3
2
1
1
Supplier
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Immunogen Rat Bcl-xL
Isotype IgG
Cross-Reactivity Human, Chicken, Dog (Canine), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from antiserum by affinity chromatography.
Alternative Name Bcl-x (BCL2L1 Antibody Abstract)
Background Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is found in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. Bcl-xS lacks 63 amino acids corresponding to the region of Bcl-xL with the highest degree of homology to Bcl-2. Like Bcl-2, Bcl-xL inhibits cell death upon growth factor withdrawal in an IL-3-dependent cell line. However, Bcl-xS inhibits the ability of Bcl-2 to enhance cell survival in the absence of growth factors.
Molecular Weight 26 kDa
Research Area Cancer
Pathways Apoptosis
Comment

Related Products: ABIN968536, ABIN967390

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-BCL2L1 antibody (BCL2-Like 1) (AA 18-233) (ABIN967829) Western blot analysis of Bcl-x on human endothelial cell lysate. Lane 1: 1:1000, lane...
Immunofluorescence (IF) image for anti-BCL2L1 antibody (BCL2-Like 1) (AA 18-233) (ABIN967829) Immunofluorescent staining of human endothelial cells.
Product cited in: Tomicic, Thust, Kaina: "Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation." in: Oncogene, Vol. 21, Issue 14, pp. 2141-53, 2002 (PubMed).

Rogers, Song, Gramaglia et al.: "OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells." in: Immunity, Vol. 15, Issue 3, pp. 445-55, 2001 (PubMed).

Jiang, Clark: "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 6025-33, 2001 (PubMed).

Wen, Wang, McKay et al.: "Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development." in: Molecular and cellular biology, Vol. 21, Issue 2, pp. 678-89, 2001 (PubMed).

Background publications Boise, González-García, Postema et al.: "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." in: Cell, Vol. 74, Issue 4, pp. 597-608, 1993 (PubMed).