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Cadherin 5 antibody (AA 26-194)

CDH5 Reactivity: Human WB, IHC, IP, IF Host: Mouse Monoclonal 75-Cadherin unconjugated
Catalog No. ABIN967858
  • Target See all Cadherin 5 (CDH5) Antibodies
    Cadherin 5 (CDH5)
    Binding Specificity
    • 16
    • 12
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 26-194
    Reactivity
    • 98
    • 61
    • 43
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 88
    • 25
    • 1
    • 1
    Mouse
    Clonality
    • 85
    • 30
    Monoclonal
    Conjugate
    • 68
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cadherin 5 antibody is un-conjugated
    Application
    • 84
    • 36
    • 35
    • 33
    • 17
    • 16
    • 15
    • 14
    • 13
    • 13
    • 9
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Cadherin 5 aa. 26-194
    Clone
    75-Cadherin
    Isotype
    IgG1
    Top Product
    Discover our top product CDH5 Primary Antibody
  • Comment

    Related Products: ABIN968536, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Corada, Zanetta, Orsenigo, Breviario, Lampugnani, Bernasconi, Liao, Hicklin, Bohlen, Dejana: "A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability." in: Blood, Vol. 100, Issue 3, pp. 905-11, (2002) (PubMed).

    Corada, Liao, Lindgren, Lampugnani, Breviario, Frank, Muller, Hicklin, Bohlen, Dejana: "Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability." in: Blood, Vol. 97, Issue 6, pp. 1679-84, (2001) (PubMed).

    Rahimi, Kazlauskas: "A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells." in: Molecular biology of the cell, Vol. 10, Issue 10, pp. 3401-7, (1999) (PubMed).

    Schmelz, Franke: "Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: the syndesmos connecting retothelial cells of lymph nodes." in: European journal of cell biology, Vol. 61, Issue 2, pp. 274-89, (1993) (PubMed).

    Suzuki, Sano, Tanihara: "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue." in: Cell regulation, Vol. 2, Issue 4, pp. 261-70, (1991) (PubMed).

  • Target
    Cadherin 5 (CDH5)
    Alternative Name
    Cadherin-5 (CDH5 Products)
    Synonyms
    7B4 antibody, AA408225 antibody, Cd144 antibody, VE-Cad antibody, VECD antibody, VEcad antibody, Vec antibody, wu:fc88a07 antibody, CD144 antibody, cadherin-5 antibody, cadherin 5 antibody, CDH5 antibody, Cdh5 antibody, cdh5 antibody
    Background
    Cadherins are a family of transmembrane glycoproteins involved in the Ca2+- dependent cell-cell adhesion that occurs in many tissues. These proteins are similar in their domain structure (45-74% amino acid conservation), Ca2+ and protease-sensitivity, and molecular weight. Cadherin-5 (VE-Cadherin or CD144) is one of a number of cadherins (cadherin-4 through -11) whose cDNAs were isolated from rat brain and retina. These cadherins have a cytoplasmic domain that is highly conserved relative to previously identified cadherins, indicating that this domain is essential for cell adhesion activity. This function is mediated by cadherin interaction with cytoskeletal proteins. However, Cadherin-5's cytoplasmic domain has the lowest degree of homology with the other cadherins. Cadherin-5 is expressed in brain and various other tissues, including umbilical cord vein endothelial cells. A new type of adhering junction has been identified in certain vascular endothelial cells. These junctions are known as complexus adherens and are morphologically and compositionally distinct from desmosomes and zonula adherens junctions. The complexus adherens of endothelial cells lack desmosomal cadherins as well as E-Cadherin. However, these cells are rich in Cadherin-5 which colocalizes with desmoplakin and gamma-Catenin (plakoglobin).
    Molecular Weight
    130 kDa
    Pathways
    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
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