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Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody

Details for Product No. ABIN967875
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Antigen
Synonyms CAMK4, camk4-A, CaMK IV, CaMK-GR, IV, caMK, A430110E23Rik, AI666733, CaMKIV, CaMKIV/Gr, D18Bwg0362e, Ccdpk, RATCCDPK, wu:fj42a03, zgc:110275
Epitope
AA 1-241
(21), (20), (18), (7), (5), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(96), (64), (57), (27), (26), (26), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(95), (14)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(83), (38), (31), (29), (24), (20), (13), (12), (5), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN967875
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Immunogen Human CaM Kinase IV
Clone MK-1-25
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CaM Kinase IV
Background CaM-kinase IV (Ca2+/calmodulin-dependent protein kinase IV, also described as CaM-kinase Gr) is activated through the binding of Ca2+/CaM and by phosphorylation. This kinase has high sequence homologies with the catalytic and regulatory domains of CaM-kinase II. CaM-kinase IV is a monomer which is highly expressed in cerebellum, thymus, and testis. Its subcellular distrubution includes localization in both the synaptic regions of the molecular layer of the cerebellum, and the nuclei of cerebellar granule cells. CaM-kinase IV has an autoinhibitory domain within residues 305-321 that can suppress kinase activity in the absence of Ca2+/CaM. This type of domain is common in many other CaM-dependent kinases and phosphatases. CaM-kinase IV does not appear to be significantly activated by autophosphorylation, but it can be activated approximately 5-10-fold when phosphorylated by CaM-kinase IV kinase.
Molecular Weight 60 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody Western blot analysis of CaM Kinase IV on Jurkat cell lysate. Lane 1: 1:5000, lane 2: 1:10000, lane 3: 1:20000 dilution of anti-CaM Kinase IV.
anti-Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody (2) Immunofluorescent staining on WI38 cells.
anti-Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody (3) Pyrimidal cells in rat cortex, formalin-fixed paraffin embedded tissue, no pre-treatment, 20X
Product cited in: Ohmstede, Bland, Merrill et al.: "Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 13, pp. 5784-8, 1991 (PubMed).

Passier, Zeng, Frey et al.: "CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo." in: The Journal of clinical investigation, Vol. 105, Issue 10, pp. 1395-406, 2000 (PubMed).

Slee, Adrain, Martin: "Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 10, pp. 7320-6, 2001 (PubMed).

Wayman, Walters, Kolibaba et al.: "CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 811-24, 2000 (PubMed).

Wei, Qiu, Liauw et al.: "Calcium calmodulin-dependent protein kinase IV is required for fear memory." in: Nature neuroscience, Vol. 5, Issue 6, pp. 573-9, 2002 (PubMed).

Validation Images
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