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Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody

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Synonyms CAMK4, camk4-A, CaMK IV, CaMK-GR, IV, caMK, A430110E23Rik, AI666733, CaMKIV, CaMKIV/Gr, D18Bwg0362e, Ccdpk, RATCCDPK, wu:fj42a03, zgc:110275
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AA 1-241
(28), (21), (20), (15), (9), (6), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(117), (87), (61), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1)
(122), (24)
Clonality (Clone)
Monoclonal ()
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(114), (58), (47), (38), (29), (22), (13), (8), (5), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human CaM Kinase IV aa. 1-241
Clone 26-CaM Kinase IV
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CaM Kinase IV (CAMK4 Antibody Abstract)
Background CaM-kinase IV (Ca2+/calmodulin-dependent protein kinase IV, also described as CaM-kinase Gr) is activated through the binding of Ca2+/CaM and by phosphorylation. This kinase has high sequence homologies with the catalytic and regulatory domains of CaM-kinase II. CaM-kinase IV is a monomer which is highly expressed in cerebellum, thymus, and testis. Its subcellular distrubution includes localization in both the synaptic regions of the molecular layer of the cerebellum, and the nuclei of cerebellar granule cells. CaM-kinase IV has an autoinhibitory domain within residues 305-321 that can suppress kinase activity in the absence of Ca2+/CaM. This type of domain is common in many other CaM-dependent kinases and phosphatases. CaM-kinase IV does not appear to be significantly activated by autophosphorylation, but it can be activated approximately 5-10-fold when phosphorylated by CaM-kinase IV kinase.
Molecular Weight 60 kDa
Pathways EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody (ABIN967875) Western blot analysis of CaM Kinase IV on Jurkat cell lysate. Lane 1: 1:5000, lane 2:...
Immunofluorescence (IF) image for anti-Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody (ABIN967875) Immunofluorescent staining on WI38 cells.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4) (AA 1-241) antibody (ABIN967875) Pyrimidal cells in rat cortex, formalin-fixed paraffin embedded tissue, no pre-treatm...
Product cited in: Wei, Qiu, Liauw et al.: "Calcium calmodulin-dependent protein kinase IV is required for fear memory." in: Nature neuroscience, Vol. 5, Issue 6, pp. 573-9, 2002 (PubMed).

Wayman, Walters, Kolibaba et al.: "CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner." in: The Journal of cell biology, Vol. 151, Issue 4, pp. 811-24, 2000 (PubMed).

Slee, Adrain, Martin: "Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 10, pp. 7320-6, 2001 (PubMed).

Passier, Zeng, Frey et al.: "CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo." in: The Journal of clinical investigation, Vol. 105, Issue 10, pp. 1395-406, 2000 (PubMed).

Ohmstede, Bland, Merrill et al.: "Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 13, pp. 5784-8, 1991 (PubMed).

Catalog No. ABIN967875
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