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FADD antibody (AA 94-208)

FADD Reactivity: Human WB, IHC, IP, IF Host: Mouse Monoclonal 1-FADD unconjugated
Catalog No. ABIN967944
  • Target See all FADD Antibodies
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Binding Specificity
    • 18
    • 15
    • 15
    • 8
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 94-208
    Reactivity
    • 88
    • 61
    • 19
    • 18
    • 15
    Human
    Host
    • 98
    • 18
    Mouse
    Clonality
    • 94
    • 22
    Monoclonal
    Conjugate
    • 68
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FADD antibody is un-conjugated
    Application
    • 90
    • 51
    • 31
    • 15
    • 15
    • 15
    • 12
    • 9
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human FADD aa. 94-208
    Clone
    1-FADD
    Isotype
    IgG1
    Top Product
    Discover our top product FADD Primary Antibody
  • Comment

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Chang, Xing, Pan, Algeciras-Schimnich, Barnhart, Yaish-Ohad, Peter, Yang: "c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis." in: The EMBO journal, Vol. 21, Issue 14, pp. 3704-14, (2002) (PubMed).

    MacFarlane, Harper, Snowden, Dyer, Barnett, Pringle, Cohen: "Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia." in: Oncogene, Vol. 21, Issue 44, pp. 6809-18, (2002) (PubMed).

    Micheau, Thome, Schneider, Holler, Tschopp, Nicholson, Briand, Grütter: "The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45162-71, (2002) (PubMed).

    Wieder, Essmann, Prokop, Schmelz, Schulze-Osthoff, Beyaert, Dörken, Daniel: "Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3." in: Blood, Vol. 97, Issue 5, pp. 1378-87, (2001) (PubMed).

  • Target
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Alternative Name
    FADD (FADD Products)
    Synonyms
    MORT1 antibody, Mort1/FADD antibody, Mort1 antibody, TNFRSF6 antibody, adaptor antibody, fadd antibody, mort1 antibody, xfadd antibody, Fas associated via death domain antibody, Fas (TNFRSF6)-associated via death domain antibody, Fas associated via death domain S homeolog antibody, Fas (tnfrsf6)-associated via death domain antibody, FADD antibody, Fadd antibody, fadd.S antibody, fadd antibody
    Background
    During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation. The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor receptor (TNF-R) can trigger cell death, as well as various other responses. Data suggested that Fas and TNF-R affect a common target in the cell death pathway. This target has been identified as FADD, a novel protein that contains a death domain homologous to the death domains of Fas and TNF-R1. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that is inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death. Thus, FADD is a central element of the Fas-mediated cell death pathway. This antibody is routinely tested by western blot analysis.
    Molecular Weight
    24 kDa
    Pathways
    Apoptosis, TLR Signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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