You are viewing an incomplete version of our website. Please click to reload the website as full version.

Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody

Details for Product No. ABIN967955, Supplier: Log in to see
Antigen
  • NMDAR2B
  • GluN2B
  • MRD6
  • NR2B
  • hNR3
  • nmdar2b
  • nr2b
  • AW490526
  • Nmdar2b
Epitope
AA 892-1051
50
47
39
35
32
27
17
16
14
14
14
13
13
13
12
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
289
285
230
15
9
8
5
4
4
4
3
2
2
1
1
Host
Mouse
291
54
14
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
12
12
10
9
9
9
9
9
9
9
9
9
5
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
BioImaging (BI), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
240
99
83
73
71
53
43
14
9
4
3
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen Rat NMDAR2B aa. 892-1051
Clone 13-NMDAR2B
Isotype IgG2b
Cross-Reactivity Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name NMDAR2B (GRIN2B Antibody Abstract)
Background The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distint types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. Three types of NMDAR2 have been identified: NR2A, NR2B, and NR2C. NR2A and NR2B contain a C-terminal extension (>600 amino acids) that has small scattered regions of conserved sequence. The three NR2 mRNAs show overlapping, differential expression patterns in the rat brain. NR2B has been reported to be expressed in the forebrain, thalamic nuclei, amygdaloid nuclei, caudateputamen, and in restricted regions of the olfactory bulb. This antibody is routinely tested by western blot analysis.
Synonyms: N-Methyl-D-Aspartate Receptor 2B
Molecular Weight 180 kDa
Research Area Neurology, Neurotransmitters, Receptors
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody (ABIN967955) Western blot analysis of NMDAR2B on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:5...
Immunofluorescence (IF) image for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (AA 892-1051) antibody (ABIN967955) Immunofluorescence staining of a rabbit brain section.
Product cited in: Yoshii, Sheng, Constantine-Paton: "Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1334-9, 2003 (PubMed).

Wong, Setou, Teng et al.: "Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14500-5, 2002 (PubMed).

Fallon, Moreau, Croft et al.: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Sun, Murali: "Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate." in: The American journal of physiology, Vol. 275, Issue 3 Pt 1, pp. C772-9, 1998 (PubMed).

Background publications Monyer, Sprengel, Schoepfer et al.: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes." in: Science (New York, N.Y.), Vol. 256, Issue 5060, pp. 1217-21, 1992 (PubMed).