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Details for Product No. ABIN967963

Nitric Oxide Synthase 2, Inducible (NOS2) (AA 961-1144) antibody

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Antigen
Synonyms NOS, INOS, NOS2A, HEP-NOS, NOS2a, iNOS, Nos-2, Nos2a, i-NOS, NOS-II, iNos, NOS2
Epitope
»Alternatives AA 961-1144
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN967963
Quantity 50 µg
Price
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Immunogen Mouse iNOS
Clone 54
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name iNOS/NOS Type II
Background Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In macrophages and other cell types, NOS (iNOS or macNOS) activity increases following exposure to cytokines (IFN-gamma, TNF-alpha, and IL-1) and microbial products (lipopolysaccharide (LPS)). iNOS is activated independently of Ca2+/calmodulin and its level of expression is tightly controlled by several transcription factors, including NFkappaB. Data indicates that TGF-beta affects translation of iNOS mRNA and decreases iNOS protein stability. Normally undetectable in brain tissue, iNOS mRNA has been observed in CNS tissues of animals under experimental pathologic conditions. iNOS and nNOS share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain. This antibody has been reported to cross-react with nNOS and eNOS.
Synonyms: NOS Type II
Molecular Weight 130 kDa
Comment

Related Products: ABIN968550, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Xie, Cho, Calaycay et al.: "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages." in: Science (New York, N.Y.), Vol. 256, Issue 5054, pp. 225-8, 1992 (PubMed).

Vodovotz, Bogdan, Paik et al.: "Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta." in: The Journal of experimental medicine, Vol. 178, Issue 2, pp. 605-13, 1993 (PubMed).

Zhao, Dugas, Mathiot et al.: "B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity." in: Blood, Vol. 92, Issue 3, pp. 1031-43, 1998 (PubMed).

Resta, ODonaughy, Earley et al.: "Unaltered vasoconstrictor responsiveness after iNOS inhibition in lungs from chronically hypoxic rats." in: The American journal of physiology, Vol. 276, Issue 1 Pt 1, pp. L122-30, 1999 (PubMed).

Zadeh, Kolb, Geromin et al.: "Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase." in: Journal of leukocyte biology, Vol. 67, Issue 3, pp. 327-34, 2000 (PubMed).

Alternatives for antigen "Nitric Oxide Synthase 2, Inducible (NOS2)", type "Antibodies"
Hosts (141), (20)
Reactivities (133), (76), (51), (24), (24), (12)
Applications (101), (59), (56), (32), (28), (27), (20), (15), (13), (7), (3), (2), (1), (1)
Conjugates (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (24), (10), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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