Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody

Details for Product No. ABIN968002, Supplier: Log in to see
Antigen
  • 11
  • CG1725
  • CG1730
  • CPD
  • DLG
  • DLG-A
  • Discs-large
  • Dlg
  • Dlg-A
  • Dlg1
  • DlgA
  • Dmel\\CG1725
  • Drodlg
  • PSD95
  • SAP97
  • anon-EST:Posey93
  • anon-WO03040301.258
  • anon-WO03040301.260
  • anon-WO03040301.268
  • d. lg.-1
  • dlg
  • dlg-1
  • dlg-A
  • dlgA
  • dlgS97
  • l(1)10Bf
  • l(1)G0276
  • l(1)G0342
  • l(1)G0456
  • l(1)G19
  • l(1)L11
  • l(1)bwn
  • l(1)d.lg-1
  • l(1)d.lg.-1
  • l(1)discs large
  • l(1)dlg
  • l(1)dlg-1
  • l(1)dlg1
  • l(1)l.pr.-2
  • l(1)lpr-2
  • misb
  • dlgh4
  • psd95
  • sap90
  • sap-90
  • LLGL1
  • Dlgh4
  • PSD-95
  • SAP90
  • SAP90A
  • Sap90
  • SAP-90
  • DLG4
  • discs large 1
  • discs, large homolog 4
  • lethal giant larvae homolog 1 (Drosophila)
  • discs, large homolog 4 (Drosophila)
  • discs, large (Drosophila) homolog 4
  • dlg1
  • dlg4
  • DLG4
  • Dlg4
  • LLGL1
Alternatives
anti-Human Discs, Large Homolog 4 (Drosophila) antibody for Flow Cytometry
Epitope
AA 353-504
15
15
15
15
15
9
6
5
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
216
207
194
96
13
13
5
5
4
4
3
3
2
2
1
1
1
1
1
Host
Mouse
145
94
14
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
9
9
7
6
5
5
5
5
5
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
206
115
110
88
45
39
36
20
19
17
13
7
2
2
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Rat PSD-95 aa. 353-504
Clone 16-PSD
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PSD-95 (DLG4 Antibody Abstract)
Background PostSynaptic Density (PSD) refers to a dense region of submembranous cytoskeleton found most prominently in postsynaptic membranes of the CNS. Possible functions for the PSD include regulation and aggregation of receptors, structural stabilization of the synaptic junction, and transduction of signals from membrane receptors. Some of the proteins associated with the PSD are fodrin, tubulin, calmodulin, CaM Kinase II, PSD-95, and PSD-93. PSD-95 (SAP90) is a protein that interacts with the NMDA receptor NMDAR2B, neuronal NOS (nNOS or bNOS), and other proteins. PSD-95 contains one SH3 domain in its carboxy-terminal domain, as well as three conserved repeat regions called GLGF or PDZ domains. nNOS, which is concentrated in synaptic junctions, also contains a PZD domain. PSD-95 and nNOS interact via their respective PZD domains, which may mediate the binding of nNOS to skeletal muscle syntrophin. This antibody is routinely tested by western blot analysis.
Synonyms: PostSynaptic Density-95, SAP90
Molecular Weight 95 kDa
Pathways Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody (ABIN968002) Western blot analysis of PSD-95 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:50...
Immunofluorescence (IF) image for anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody (ABIN968002) Immunofluorescence staining of PC12 cells (Rat neuroblastoma, ATCC CRL-1721).
Product cited in: Fagiolini, Katagiri, Miyamoto, Mori, Grant, Mishina, Hensch: "Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2854-9, 2003 (PubMed).

Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Mehta, Wu, Garner, Marshall: "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16092-9, 2001 (PubMed).

Brenman, Chao, Gee, McGee, Craven, Santillano, Wu, Huang, Xia, Peters, Froehner, Bredt: "Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains." in: Cell, Vol. 84, Issue 5, pp. 757-67, 1996 (PubMed).

Background publications Cho, Hunt, Kennedy: "The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein." in: Neuron, Vol. 9, Issue 5, pp. 929-42, 1992 (PubMed).

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