Glutamine Synthetase (GLN1) (AA 1-373) antibody

Details for Product No. ABIN968014, Supplier: Log in to see
Antigen
  • GLNS
  • GS
  • PIG43
  • PIG59
  • Glns
  • glutamate-ammonia ligase
  • glutamate-ammonia ligase (glutamine synthetase)
  • glutamine synthetase
  • GLUL
  • Glul
  • GLN1
Alternatives
anti-Rat (Rattus) Glutamine Synthetase antibody for BioImaging
Epitope
AA 1-373
15
8
8
7
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
54
34
30
4
3
3
3
2
2
1
1
1
1
1
1
1
1
Host
Mouse
42
17
7
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
BioImaging (BI), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
47
29
22
13
12
9
8
6
3
3
2
2
1
Options
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Immunogen Human Glutamine Synthetase aa. 1-373
Clone 6-Glutamine Synthetase
Isotype IgG2a
Cross-Reactivity Rat (Rattus), Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Glutamine Synthetase (GLN1 Antibody Abstract)
Background Glutamine synthetase catalyzes the amination of glutamic acid to form glutamine. It is found in mammals as an octamer of identical 45 kDa subunits. Glutamine synthetase activity is a useful marker for astrocytes and an important differentiation feature in retina. It is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate. This antibody is routinely tested by western blot analysis.
Molecular Weight 45 kDa
Research Area Neurology, Alzheimer's Disease, Amino Acids, Enzymes, Metabolism
Pathways Positive Regulation of Peptide Hormone Secretion
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Glutamine Synthetase (GLN1) (AA 1-373) antibody (ABIN968014) Western blot analysis of glutamine synthetase on a rat cerebrum lysate. Lane 1: 1:500...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Glutamine Synthetase (GLN1) (AA 1-373) antibody (ABIN968014) Glutamine synthetase staining on a rat cerebrum section. Section prepared during anti...
Product cited in: Kronfeld, Kazimirsky, Lorenzo, Garfield, Blumberg, Brodie: "Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35491-8, 2000 (PubMed).

Labow, Souba, Abcouwer: "Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms." in: The American journal of physiology, Vol. 276, Issue 6 Pt 1, pp. E1136-45, 1999 (PubMed).

Fei, DAmbrosio, Li, Surmacz, Baserga: "Association of insulin receptor substrate 1 with simian virus 40 large T antigen." in: Molecular and cellular biology, Vol. 15, Issue 8, pp. 4232-39, 1995 (PubMed).

Kentroti, Baker, Lee, Bruce, Vernadakis: "Platelet-activating factor increases glutamine synthetase activity in early and late passage C-6 glioma cells." in: Journal of neuroscience research, Vol. 28, Issue 4, pp. 497-506, 1991 (PubMed).

Vardimon, Fox, Cohen-Kupiec, Degenstein, Moscona: "Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5275-84, 1991 (PubMed).