Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B) (AA 107-268) antibody

Details for Product No. ABIN968022
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Antigen
Synonyms AIDA, AIDA-1, ANKS2, EB-1, EB1, cajalin-2, AIDA-1b, C030032C09Rik, E530015N03Rik, ENSMUSG00000078431, Gm10937, Gm1555, RGD1565556, si:ch211-146a9.3, si:dkey-11k24.3, COX7AR, COX7RP, SIG81
Epitope
AA 107-268
(7), (6), (4), (2), (1)
Reactivity
Human
(28), (15), (13), (12), (1)
Host
Mouse
(27), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (ffpe))
(20), (10), (8), (7), (4), (2), (2)
Pubmed 5 references available
Quantity 150 µg
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Catalog No. ABIN968022
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Immunogen Human EB1
Clone 5
Isotype IgG1
Cross-Reactivity Chicken, Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name EB1
Background Familial adenomatous polyposis is an autosomal inherited disease characterized by mutations in the APC (adenomatous polyposis coli) gene. Individuals with this disease are predisposed to colorectal polyps and cancer. It has been proposed that disruption of the APC gene plays a role in the disease. APC is a large coiled-coil protein that interacts, via its carboxy terminus, with catenins and with the protein, EB1. This 30 kDa protein was discovered as a result of its strong binding to the C-terminal domain of APC. Like the APC-binding proteins beta-Catenin and pp120Cas, EB1 may play an essential role in modulating APC activity and tumorigenesis. This antibody is routinely tested by western blot analysis.
Molecular Weight 30 kDa
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B) (AA 107-268) antibody Western blot analysis of EB1 on a human endothelial cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the anti- EB1 antibody.
anti-Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B) (AA 107-268) antibody (2) Immunofluorescence staining of human intestinal smooth muscle cells (HISM).
anti-Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B) (AA 107-268) antibody (3) anti-Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B) (AA 107-268) antibody (Image 3)
Product cited in: Su, Huang, Fair et al.: "Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression." in: Cancer research, Vol. 55, Issue 7, pp. 1441-3, 1995 (PubMed).

Mamane, Grandvaux, Hernandez et al.: "Repression of IRF-4 target genes in human T cell leukemia virus-1 infection." in: Oncogene, Vol. 21, Issue 44, pp. 6751-65, 2002 (PubMed).

Askham, Vaughan, Goodson et al.: "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome." in: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3627-45, 2002 (PubMed).

Komarova, Akhmanova, Kojima et al.: "Cytoplasmic linker proteins promote microtubule rescue in vivo." in: The Journal of cell biology, Vol. 159, Issue 4, pp. 589-99, 2002 (PubMed).

Etienne-Manneville, Hall: "Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity." in: Nature, Vol. 421, Issue 6924, pp. 753-6, 2003 (PubMed).

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