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Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) antibody

Details for Product No. ABIN968031
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Antigen
Synonyms dusp3, si:bz18k17.3, si:rp71-18k17.3, VHR, RGD1560049, 2210015O03Rik, 5031436O03Rik, T-DSP11
Epitope
AA 1-185
(7), (6), (4), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(46), (13), (13), (12), (12)
Host
Mouse
(36), (10)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
(27), (24), (12), (11), (10), (3), (3), (2), (2), (1)
Pubmed 4 references available
Quantity 150 µg
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Catalog No. ABIN968031
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Immunogen Human VHR
Clone 24
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name VHR
Background Protein tyrosine phosphatases (PTP) have been implicated in cell proliferation, cell signaling, and oncogenic transformation. More members of the PTP family of proteins have been found by screening libraries with cDNA at low stringency hybridization. VHR, a prototype for PTP, is a vaccinia-virus (VH-1)-related phosphatase of 185 amino acids with activity against phosphotyrosine and phosphoserine. In vitro, VHR is capable of dephosphorylating several growth factor receptors. In conjunction with insulin or progesterone, VHR accelerates germinal vesicle breakdown of Xenopus oocytes. These findings suggest that VHR is implicated in the regulation of cyclin-dependent kinases during the cell cycle.
Molecular Weight 20 kDa
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) antibody Western blot analysis of VHR on Jurkat lysate. Lane 1: 1:250, lane 2: 1:500, Lane 3: 1:1000 dilution of VHR.
anti-Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) antibody (2) Rabbit Liver
anti-Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) antibody (3) anti-Dual Specificity Phosphatase 3 (DUSP3) (AA 1-185) antibody (Image 3)
Product cited in: Ishibashi, Bottaro, Chan et al.: "Expression cloning of a human dual-specificity phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 12170-4, 1993 (PubMed).

Aroca, Bottaro, Ishibashi et al.: "Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14229-34, 1995 (PubMed).

Yuvaniyama, Denu, Dixon et al.: "Crystal structure of the dual specificity protein phosphatase VHR." in: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1328-31, 1996 (PubMed).

Alonso, Saxena, Williams et al.: "Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4766-71, 2001 (PubMed).

Validation Images
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