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Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-163) antibody

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Synonyms CG12019, CPDR-1, CPDR-2, DROCPDR, Dmel\\CG12019, E(sev)3B, cdc37, Afu4g10010, P50CDC37, p50, p50Cdc37
AA 1-163
(18), (17), (15), (13), (11), (10), (5), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(126), (45), (42), (4), (2), (2), (1)
(125), (4)
Clonality (Clone)
Monoclonal ()
(5), (5), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(114), (49), (48), (37), (25), (18), (18), (11), (9), (1), (1)
Pubmed 3 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human CDC37 aa. 1-163
Clone 15-Cdc37
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Cdc37 (CDC37 Antibody Abstract)
Background Progression through the cell cycle is determined by numerous extracellular factors that convey their messages to the cyclin-dependent kinases (cdk). Cdks are regulated by factors such as the availability of cyclins, inhibitors like Cip1 and Kip1, and phosphatases. CDC37 (50kDa), a regulator of the cell cycle, targets Cdk4. CDC37 was identified in a complex with pp60v-src and Raf-1. In vitro assays revealed CDC37 as a subunit of Hsp90 which associates with Cdk4. The overall result of this binding appears to be a shorter half-life of Cdk4.
Molecular Weight 50 kDa
Research Area Chromatin and Nuclear Signaling, Cell Cycle, Kinases/Phosphatases
Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-163) antibody (ABIN968047) Western blot analysis of CDC37 on human endothelial lysate. Lane 1: 1:1000, lane 2: 1...
 image for anti-Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-163) antibody (ABIN968047) WI38
 image for anti-Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-163) antibody (ABIN968047) anti-Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-163) antibody (Image 3)
Product cited in: Lange, Rebollo, Herold et al.: "Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes." in: The EMBO journal, Vol. 21, Issue 20, pp. 5364-74, 2002 (PubMed).

Grammatikakis, Lin, Grammatikakis et al.: "p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function." in: Molecular and cellular biology, Vol. 19, Issue 3, pp. 1661-72, 1999 (PubMed).

Stepanova, Leng, Parker et al.: "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4." in: Genes & development, Vol. 10, Issue 12, pp. 1491-502, 1996 (PubMed).

Catalog No. ABIN968047
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