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Details for Product No. ABIN968047

Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) (AA 1-163) antibody

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Antigen
Synonyms P50CDC37, CG12019, CPDR-1, CPDR-2, DROCPDR, Dmel\\CG12019, E(sev)3B, cdc37, Afu4g10010
Epitope
»Alternatives AA 1-163
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968047
Quantity 50 µg
Price
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Immunogen Human CDC37
Clone Ghr5
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Cdc37
Background Progression through the cell cycle is determined by numerous extracellular factors that convey their messages to the cyclin-dependent kinases (cdk). Cdks are regulated by factors such as the availability of cyclins, inhibitors like Cip1 and Kip1, and phosphatases. CDC37 (50kDa), a regulator of the cell cycle, targets Cdk4. CDC37 was identified in a complex with pp60v-src and Raf-1. In vitro assays revealed CDC37 as a subunit of Hsp90 which associates with Cdk4. The overall result of this binding appears to be a shorter half-life of Cdk4.
Molecular Weight 50 kDa
Research Area Chromatin and Nuclear Signaling, Cell Cycle, Kinases/Phosphatases
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Stepanova, Leng, Parker et al.: "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4." in: Genes & development, Vol. 10, Issue 12, pp. 1491-502, 1996 (PubMed).

Grammatikakis, Lin, Grammatikakis et al.: "p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function." in: Molecular and cellular biology, Vol. 19, Issue 3, pp. 1661-72, 1999 (PubMed).

Lange, Rebollo, Herold et al.: "Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes." in: The EMBO journal, Vol. 21, Issue 20, pp. 5364-74, 2002 (PubMed).

Alternatives for antigen "Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37)", type "Antibodies"
Hosts (48), (6)
Reactivities (53), (34), (32), (12), (12), (12), (1)
Applications (43), (22), (20), (18), (14), (10), (6), (5), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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