Paxillin (PXN) (AA 1-557) antibody

Details for Product No. ABIN968067
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Antigen
Synonyms CG18061, CG18576, CG31794, CT40481, CT42454, DPaxillin, DPxn, DPxn37, Dmel\\CG31794, Dpax, DpaxA, PDLP, dPax, pax, PXN, LOC100220858, AW108311, AW123232, Pax, wu:fw71f12
Epitope
AA 1-557
(50), (46), (33), (25), (22), (18), (17), (11), (10), (8), (6), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken
(340), (171), (161), (48), (40), (25), (2), (1), (1)
Host
Mouse
(336), (33), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
(278), (96), (73), (70), (69), (47), (22), (20), (14), (4), (4), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 150 μg
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Catalog No. ABIN968067
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Immunogen Chicken Paxillin
Clone RBU-01
Isotype IgG1
Cross-Reactivity Human, Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Paxillin
Background Paxillin, a focal adhesion protein, is a substrate for several tyrosine kinases such as src, FAK, and p120BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. This is consisent with the possibility that paxillin is involved in the regulation of cell morphology. Additionally, because of its SH3 binding domain, paxillin associates tightly with FAK and Crk in an extracellular matrix-independent manner. Paxillin was initially detected in fibroblasts, and its phosphorylation may be important during neurite extension during differentiation. This antibody is routinely tested by western blot analysis.
Molecular Weight 68 kDa
Research Area Cancer, Extracellular Matrix
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Paxillin (PXN) (AA 1-557) antibody Immunofluorescent staining of WI38 cells with anti-Paxillin.
anti-Paxillin (PXN) (AA 1-557) antibody (2) Western blot analysis of Paxillin of human endothelial cell lysate. Lane 1: 1:1000, lane 2: 1: 2000, lane 3: 1: 4000 dilution of anti-Paxillin.
anti-Paxillin (PXN) (AA 1-557) antibody (3) anti-Paxillin (PXN) (AA 1-557) antibody (Image 3)
Product cited in: Turner, Glenney, Burridge: "Paxillin: a new vinculin-binding protein present in focal adhesions." in: The Journal of cell biology, Vol. 111, Issue 3, pp. 1059-68, 1990 (PubMed).

Salgia, Li, Lo et al.: "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL." in: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5039-47, 1995 (PubMed).

Müller, Jung, Wied et al.: "Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4553-67, 2001 (PubMed).

Laukaitis, Webb, Donais et al.: "Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1427-40, 2001 (PubMed).

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