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SNRPN antibody (AA 14-174)

SNRPN Reactivity: Human, Mouse, Rat, Dog WB, IF, BI, IHC (f) Host: Mouse Monoclonal 8-SMN unconjugated
Catalog No. ABIN968085
  • Target See all SNRPN Antibodies
    SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
    Binding Specificity
    • 11
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 14-174
    Reactivity
    • 30
    • 12
    • 11
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 25
    • 5
    Mouse
    Clonality
    • 27
    • 3
    Monoclonal
    Conjugate
    • 20
    • 2
    • 2
    • 2
    • 2
    • 2
    This SNRPN antibody is un-conjugated
    Application
    • 30
    • 18
    • 16
    • 6
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Alexa Fluor is a registered trademark of Molecular Probes, Inc., Eugene, OR.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    5. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human SMN aa. 14-174
    Clone
    8-SMN
    Isotype
    IgG1
    Top Product
    Discover our top product SNRPN Primary Antibody
  • Comment

    Related Products: ABIN968587, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Briese, Richter, Sattelle, Ulfig: "SMN, the product of the spinal muscular atrophy-determining gene, is expressed widely but selectively in the developing human forebrain." in: The Journal of comparative neurology, Vol. 497, Issue 5, pp. 808-16, (2006) (PubMed).

    Côté, Boisvert, Boulanger, Bedford, Richard: "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 274-87, (2003) (PubMed).

    Wang, Reddy, Shen: "Higher order arrangement of the eukaryotic nuclear bodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13583-8, (2002) (PubMed).

    Claus, Doring, Gringel, Muller-Ostermeyer, Fuhlrott, Kraft, Grothe: "Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 479-85, (2002) (PubMed).

    Cifuentes-Diaz, Frugier, Tiziano, Lacène, Roblot, Joshi, Moreau, Melki: "Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy." in: The Journal of cell biology, Vol. 152, Issue 5, pp. 1107-14, (2001) (PubMed).

  • Target
    SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
    Alternative Name
    SMN (SNRPN Products)
    Synonyms
    SNRB' antibody, SNRPB' antibody, Snrpn antibody, zgc:77315 antibody, HCERN3 antibody, PWCR antibody, RT-LI antibody, SM-D antibody, SMN antibody, SNRNP-N antibody, SNURF-SNRPN antibody, sm-N antibody, 2410045I01Rik antibody, Peg4 antibody, Pwcr1 antibody, FE 294 antibody, FE 294 psi antibody, FE294 antibody, FE294 psi antibody, SNURF antibody, SNRPN antibody, QflA-11237 antibody, QtrA-10022 antibody, Sm-N antibody, SmN antibody, snRNP-N antibody, small nuclear ribonucleoprotein polypeptide-like antibody, small nuclear ribonucleoprotein polypeptides B and B1 antibody, small nuclear ribonucleoprotein polypeptide N antibody, small nuclear ribonucleoprotein N antibody, small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 antibody, SNRPN upstream reading frame antibody, Small nuclear ribonucleoprotein-associated protein N antibody, SNRPL antibody, snrpb antibody, SNRPN antibody, Snrpn antibody, snrpn antibody, SNURF antibody
    Background
    SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40 kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0 µm within the nucleus. These novel nuclear structures were named gems and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.
    Synonyms: Survival Motor Neuron
    Molecular Weight
    40 kDa
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