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Details for Product No. ABIN968095

Death-Associated Protein 3 (DAP3) (AA 98-248) antibody

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Antigen
Synonyms DAP-3, 4921514D13Rik, MRP-S29, MRPS29, bMRP-10
Epitope
»Alternatives AA 98-248
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN968095
Quantity 50 µg
Price
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Immunogen Human DAP3
Clone 4B9
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name DAP3
Background Chronic exposure to interferons inhibits cell proliferation and results in cell death. The gene for the Death Associated Protein-3 (DAP3) was identified using a novel approach named Technical Knockout. Briefly, HeLa cells were tranfected with an antisense cDNA expression library, then exposed to interferon-gamma. Surviving cells were rescued and the anti-sense protecting genes were isolated. Several genes were identified, including one for DAP3. The DAP3 gene was found widely expressed and, as predicted, DAP3 antisense mRNA protected HeLa cells from the killing effects of interferon-gamma. Thus, this novel protein lies somewhere in the signaling downstream of interferon-gamma induced cell death.
Synonyms: Death Associated Protein-3
Molecular Weight 46 kDa
Research Area Apoptosis/Necrosis, DNA/RNA
Comment

Related Products: ABIN968552, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Kissil, Deiss, Bayewitch et al.: "Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death." in: The Journal of biological chemistry, Vol. 270, Issue 46, pp. 27932-6, 1996 (PubMed).

Kim, Suh, Sporn et al.: "An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22320-9, 2002 (PubMed).

Fulda, Debatin: "IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway." in: Oncogene, Vol. 21, Issue 15, pp. 2295-308, 2002 (PubMed).

Pedersen, Kitada, Schimmer et al.: "The triterpenoid CDDO induces apoptosis in refractory CLL B cells." in: Blood, Vol. 100, Issue 8, pp. 2965-72, 2002 (PubMed).

Alternatives for antigen "Death-Associated Protein 3 (DAP3)", type "Antibodies"
Hosts (28), (10), (7)
Reactivities (42), (17), (12)
Applications (33), (14), (9), (5), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (3), (2), (2), (1)
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