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Annexin A7 (ANXA7) (AA 34-159) antibody

Details for Product No. ABIN968100
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Antigen
Synonyms anxa7, MGC76267, ANXA7, ANX7, MGC82023, MGC83033, SNX, SYNEXIN, AI265384, AI316497, Anx7, synexin
Epitope
AA 34-159
(6), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(52), (30), (30), (26), (25), (24)
Host
Mouse
(49), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
(36), (20), (13), (10), (10), (8), (7), (3), (2)
Pubmed 5 references available
Quantity 150 µg
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Catalog No. ABIN968100
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Immunogen Human Annexin VII
Clone 5
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Annexin VII
Background Annexin VII, also known as synexin, is a member of the Annexin family characterized by Ca2+ dependent phospholipid binding. Annexins have a four-fold internal repeat of about 70 amino acids that contains the Ca2+-binding sites. They also have a regulatory NH2-terminal region of 30-40 amino acids. Annexin VII mRNA has been detected in many tissues and is most abundant in brain, heart, skeletal muscle, and lung. Annexin VII mRNA exhibits a tissue dependent polymorphism due to alternative splicing which results in two different isoforms of 47 kDa and 51 kDa. In vitro, Annexin VII aggregates chromaffin granules and enhances membrane fusion in a Ca2+ and GTP-dependent manner. Although the physiological role of Annexin VII is not completely understood, it is believed to influence and regulate Ca2+ dependent events such as secretion at the plasma membrane.
Synonyms: Synexin
Molecular Weight 51 kDa
Research Area Signaling
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Annexin A7 (ANXA7) (AA 34-159) antibody Western blot analysis of Annexin VII on a human endothelial cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti-human Annexin VII antibody.
anti-Annexin A7 (ANXA7) (AA 34-159) antibody (2) Immunofluorescence staining of human endothelial cells.
anti-Annexin A7 (ANXA7) (AA 34-159) antibody (3) anti-Annexin A7 (ANXA7) (AA 34-159) antibody (Image 3)
Product cited in: Magendzo, Shirvan, Cultraro et al.: "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3228-32, 1991 (PubMed).

Selbert, Fischer, Pongratz et al.: "Expression and localization of annexin VII (synexin) in muscle cells." in: Journal of cell science, Vol. 108 ( Pt 1), pp. 85-95, 1995 (PubMed).

Furge, Chen, Cohen: "Annexin VII and annexin XI are tyrosine phosphorylated in peroxovanadate-treated dogs and in platelet-derived growth factor-treated rat vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33504-9, 1999 (PubMed).

Srivastava, Bubendorf, Srikantan et al.: "ANX7, a candidate tumor suppressor gene for prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4575-80, 2001 (PubMed).

Salzer, Hinterdorfer, Hunger et al.: "Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin." in: Blood, Vol. 99, Issue 7, pp. 2569-77, 2002 (PubMed).

Validation Images
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