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Annexin VII antibody (Annexin A7) (AA 34-159)

Details for Product anti-ANXA7 Antibody No. ABIN968100, Supplier: Log in to see
Antigen
  • anxa7
  • MGC76267
  • ANXA7
  • ANX7
  • MGC82023
  • MGC83033
  • SNX
  • SYNEXIN
  • AI265384
  • AI316497
  • Anx7
  • synexin
Epitope
AA 34-159
14
14
8
6
5
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
77
28
25
4
2
2
2
2
1
Host
Mouse
66
9
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Annexin VII antibody is un-conjugated
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
63
30
26
16
14
12
11
8
2
1
1
1
1
1
Supplier
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Immunogen Human Annexin VII aa. 34-159
Clone 5-Annexin VII
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Annexin VII (ANXA7 Antibody Abstract)
Background Annexin VII, also known as synexin, is a member of the Annexin family characterized by Ca2+ dependent phospholipid binding. Annexins have a four-fold internal repeat of about 70 amino acids that contains the Ca2+-binding sites. They also have a regulatory NH2-terminal region of 30-40 amino acids. Annexin VII mRNA has been detected in many tissues and is most abundant in brain, heart, skeletal muscle, and lung. Annexin VII mRNA exhibits a tissue dependent polymorphism due to alternative splicing which results in two different isoforms of 47 kDa and 51 kDa. In vitro, Annexin VII aggregates chromaffin granules and enhances membrane fusion in a Ca2+ and GTP-dependent manner. Although the physiological role of Annexin VII is not completely understood, it is believed to influence and regulate Ca2+ dependent events such as secretion at the plasma membrane.
Synonyms: Synexin
Molecular Weight 51 kDa
Research Area Signaling
Pathways
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Annexin VII antibody (Annexin A7) (AA 34-159) (ABIN968100) Western blot analysis of Annexin VII on a human endothelial cell lysate. Lane 1: 1:10...
Immunofluorescence (IF) image for anti-Annexin VII antibody (Annexin A7) (AA 34-159) (ABIN968100) Immunofluorescence staining of human endothelial cells.
 image for anti-Annexin VII antibody (Annexin A7) (AA 34-159) (ABIN968100) anti-Annexin A7 (ANXA7) (AA 34-159) antibody (Image 3)
Western Blotting (WB) image for anti-Annexin VII antibody (Annexin A7) (AA 34-159) (ABIN968100) anti-Annexin A7 (ANXA7) (AA 34-159) antibody (Image 4)
Product cited in: Salzer, Hinterdorfer, Hunger et al.: "Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin." in: Blood, Vol. 99, Issue 7, pp. 2569-77, 2002 (PubMed).

Srivastava, Bubendorf, Srikantan et al.: "ANX7, a candidate tumor suppressor gene for prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4575-80, 2001 (PubMed).

Furge, Chen, Cohen: "Annexin VII and annexin XI are tyrosine phosphorylated in peroxovanadate-treated dogs and in platelet-derived growth factor-treated rat vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33504-9, 1999 (PubMed).

Selbert, Fischer, Pongratz et al.: "Expression and localization of annexin VII (synexin) in muscle cells." in: Journal of cell science, Vol. 108 ( Pt 1), pp. 85-95, 1995 (PubMed).

Magendzo, Shirvan, Cultraro et al.: "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3228-32, 1991 (PubMed).