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MAPT antibody (Microtubule-Associated Protein tau) (AA 23-179)

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Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Alternatives
Epitope
AA 23-179
(60), (41), (40), (38), (36), (36), (34), (33), (29), (29), (29), (26), (25), (20), (17), (17), (17), (14), (14), (13), (13), (13), (12), (12), (11), (11), (11), (10), (10), (10), (10), (10), (10), (8), (8), (8), (8), (7), (7), (7), (6), (6), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(986), (428), (398), (82), (20), (18), (16), (11), (9), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(937), (108), (11), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
This MAPT antibody is un-conjugated
(27), (9), (8), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
BioImaging (BI), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(884), (350), (294), (103), (94), (69), (43), (22), (14), (12), (12), (12), (12), (11), (6), (3), (2), (1)
Pubmed 5 references available
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Quantity 50 μg
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Immunogen Human Tau Recombinant Protein
Clone 15-Tau
Isotype IgG2b, kappa
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Tau (MAPT Antibody Abstract)
Background In addition to tubulin, microtubules have other components named Microtubule-associated proteins (MAPs), which include the high molecular MAPs (200-400 kDa) and the Tau proteins (55-70 kDa). These proteins co-purify with the microtubules during repeated cycles of microtubule assembly and disassembly. Both MAPs and Tau proteins extend from the side of the microtubules. They form cross-bridges in neurons and bind tubulin by their C-terminal region. The heterogeneity in the molecular weight of Tau proteins is due to post-translational modifications and different numbers of tandem repeats in their C-terminal domain. Tau isoforms are selectively expressed in unique subsets of neurons and regulated during development. The highly phosphorylated Tau proteins have also been detected in the neurofibrillary tangles of Alzheimer's patients. This antibody is routinely tested by western blot analysis.
Molecular Weight 50-68 kDa
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Pathways MAPK Signaling, Microtubule Dynamics
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-MAPT antibody (Microtubule-Associated Protein tau) (AA 23-179) (ABIN968103) Western blot analysis of Tau on a rat cerebrum lysate. Lane 1: 1:1000, lane 2: 1:2000...
Image no. 2 for anti-MAPT antibody (Microtubule-Associated Protein tau) (AA 23-179) (ABIN968103) Immunoflourescence staining of rat neurons.
Image no. 3 for anti-MAPT antibody (Microtubule-Associated Protein tau) (AA 23-179) (ABIN968103) anti-Microtubule-Associated Protein tau (MAPT) (AA 23-179) antibody (Image 3)
Immunofluorescence (IF) image for anti-MAPT antibody (Microtubule-Associated Protein tau) (AA 23-179) (ABIN968103) anti-Microtubule-Associated Protein tau (MAPT) (AA 23-179) antibody (Image 4)
Western Blotting (WB) image for anti-MAPT antibody (Microtubule-Associated Protein tau) (AA 23-179) (ABIN968103) anti-Microtubule-Associated Protein tau (MAPT) (AA 23-179) antibody (Image 5)
Product cited in: Takeda, Hatai, Hamazaki et al.: "Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells." in: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9805-13, 2000 (PubMed).

Wilson, Binder: "Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease." in: The American journal of pathology, Vol. 150, Issue 6, pp. 2181-95, 1997 (PubMed).

Alonso, Grundke-Iqbal, Iqbal: "Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules." in: Nature medicine, Vol. 2, Issue 7, pp. 783-7, 1996 (PubMed).

Kanai, Hirokawa: "Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding." in: Neuron, Vol. 14, Issue 2, pp. 421-32, 1995 (PubMed).

Goedert, Spillantini, Potier et al.: "Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain." in: The EMBO journal, Vol. 8, Issue 2, pp. 393-9, 1989 (PubMed).

Catalog No. ABIN968103
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