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Caveolin 2 (CAV2) (AA 42-162) antibody

Details for Product No. ABIN968108
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Antigen
Synonyms cav-2, CAV2, CAV-2, zgc:86696, wu:fc52e01, caveolin-2, Cav-2, cav, Caveolin-2, cav2, CAV, AI447843
Epitope
AA 42-162
(12), (12), (12), (7), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(57), (27), (26), (2), (1), (1), (1)
Host
Mouse
(69), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(51), (18), (16), (9), (8), (7), (4), (3), (3)
Pubmed 6 references available
Quantity 50 µg
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Catalog No. ABIN968108
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Immunogen Human Caveolin 2
Clone 65
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Caveolin 2
Background Identified as a tyrosine phosphorylated protein in Rous sarcoma virus- transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Although caveolin 2 is similar to caveolin 1 in distribution and tissue expression, caveolin 2 is most abundant in adipose tissue and its expression is up-regulated upon differentiation. This antibody has been reported to recognize an epitope located within region 79-88 of caveolin 2.
Molecular Weight 20 kDa
Research Area Cardiovascular, Atherosclerosis, Organelles
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Caveolin 2 (CAV2) (AA 42-162) antibody Western blot analysis of Caveolin 2 on a RSV-3T3 cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-Caveolin 2 antibody.
anti-Caveolin 2 (CAV2) (AA 42-162) antibody (2) Immunoflurorescence staining of FHs cells (Normal human fetal lung fibroblasts, ATCC HTB-157).
Product cited in: Scherer, Okamoto, Chun et al.: "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 1, pp. 131-5, 1996 (PubMed).

Das, Lewis, Scherer et al.: "The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo." in: The Journal of biological chemistry, Vol. 274, Issue 26, pp. 18721-8, 1999 (PubMed).

Kiss, Túri, Müllner et al.: "Caveolin isoforms in resident and elicited rat peritoneal macrophages." in: European journal of cell biology, Vol. 79, Issue 5, pp. 343-9, 2000 (PubMed).

Zschocke, Manthey, Bayatti et al.: "Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38772-80, 2002 (PubMed).

Woodman, Park, Cohen et al.: "Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38988-97, 2002 (PubMed).

Tauchi-Sato, Ozeki, Houjou et al.: "The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44507-12, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968108
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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