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Protein Kinase N1 (PKN1) (AA 215-388) antibody

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3-2, CG2049, CG2055, CT6637, CT6660, DPKN, Dmel\\CG2049, Dpkn, PKN, PRK2, Pk45C, Pk?3, dPKN, l(2)06736, l(2)45Ca, v(2)rG232, PKN1, EGVEGF, PK1, PRK1, DBK, PAK-1, PAK1, PKN-ALPHA, PRKCL1, F730027O18Rik ... show more
3-2, CG2049, CG2055, CT6637, CT6660, DPKN, Dmel\\CG2049, Dpkn, PKN, PRK2, Pk45C, Pk?3, dPKN, l(2)06736, l(2)45Ca, v(2)rG232, PKN1, EGVEGF, PK1, PRK1, DBK, PAK-1, PAK1, PKN-ALPHA, PRKCL1, F730027O18Rik, Pkn, Prkcl1, Stk3 show less
AA 215-388
(6), (5), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(38), (8), (8), (2), (2), (1)
(32), (7)
Clonality (Clone)
Monoclonal ()
(1), (1)
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(34), (13), (6), (6), (4), (4), (3), (3), (1), (1), (1)
Pubmed 4 references available
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Quantity 150 μg
Shipping to United States ( )
Immunogen Human PRK1 aa. 215-388
Clone 49-PRK1
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PRK1 (PKN1 Antibody Abstract)
Background Members of the Protein Kinase C (PKC) family of homologous serine/threonine protein kinases are involved in a number of processes such as cell growth, cell differentiation, and cytokine secretion. PKCs are activated by Ca2+, phospholipids, diacylglycerol, phorbol esters, and proteolysis. PRK1 (PKC-Related Kinase 1, also named PKN) was originally identified in human hippocampus as a novel protein kinase with sequence homology to PKC. PRK1 contains 942 amino acids with an apparent molecular weight of 120 kDa. Although activated by limited proteolysis, PRK1 is not activated by Ca2+/diacylglycerol or phorbol esters. However, PRK1 is activated by phospholipids and arachidonic acid. PRK1 may regulate cytoskeletal changes since it binds to Rho-GTP and becomes phosphorylated in vivo, coincidentally with the formation of focal adhesions and stress fibers.
Synonyms: PKN
Molecular Weight 120 kDa

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Protein Kinase N1 (PKN1) (AA 215-388) antibody (ABIN968111) Western blot analysis of PRK1 on Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane ...
Image no. 2 for anti-Protein Kinase N1 (PKN1) (AA 215-388) antibody (ABIN968111) MCF7 cells (ATCC HTB-22)
Image no. 3 for anti-Protein Kinase N1 (PKN1) (AA 215-388) antibody (ABIN968111) anti-Protein Kinase N1 (PKN1) (AA 215-388) antibody (Image 3)
Product cited in: Hughes, Larijani, Parker: "Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22974-9, 2002 (PubMed).

Flynn, Mellor, Casamassima et al.: "Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase." in: The Journal of biological chemistry, Vol. 275, Issue 15, pp. 11064-70, 2000 (PubMed).

Mukai, Kitagawa, Shibata et al.: "Activation of PKN, a novel 120-kDa protein kinase with leucine zipper-like sequences, by unsaturated fatty acids and by limited proteolysis." in: Biochemical and biophysical research communications, Vol. 204, Issue 1, pp. 348-56, 1994 (PubMed).

Palmer, Ridden, Parker: "Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family." in: European journal of biochemistry / FEBS, Vol. 227, Issue 1-2, pp. 344-51, 1995 (PubMed).

Catalog No. ABIN968111
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