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Details for Product No. ABIN968126

A Kinase (PRKA) Anchor Protein 11 (AKAP11) (AA 11-173) antibody

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Antigen
Synonyms Akap, AKAP-11, AKAP220, PPP1R44, PRKA11, Gm80, mKIAA0629, 6330501D17Rik, AKAP11, prka11, akap220
Epitope
»Alternatives AA 11-173
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN968126
Quantity 150 µg
Price
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Immunogen Rat AKAP220
Clone 7H3
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name AKAP220
Background The type II cAMP-dependent Protein Kinase (PKA) is compartmentalized within the cell. To maintain this localization of type II PKAs, the regulatory subunit (RII) interacts with RII-anchoring proteins. For instance, attachment of type II PKA to the cytoskeleton occurs through the binding of RII to microtubule associated-protein 2. In brain, several proteins have been identified as PKA type II anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). AKAP220 is a protein of 1129 amino acids with a PKARII binding site and a CRL motif at the COOH terminus, characteristic of peroxisomal proteins. AKAP220 mRNA is expressed ubiquitously with the highest levels in testis and brain. Immunolocalization studies confirmed the peroxisomal distribution of both AKAP220 and PKARII in a cell line derived from rat Sertoli cells.
Molecular Weight 220 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Lester, Coghlan, Nauert et al.: "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes." in: The Journal of biological chemistry, Vol. 271, Issue 16, pp. 9460-5, 1996 (PubMed).

DellAcqua, Scott: "Protein kinase A anchoring." in: The Journal of biological chemistry, Vol. 272, Issue 20, pp. 12881-4, 1997 (PubMed).

Tanji, Yamamoto, Yorioka et al.: "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 36955-61, 2002 (PubMed).

Alternatives for antigen "A Kinase (PRKA) Anchor Protein 11 (AKAP11)", type "Antibodies"
Hosts (7), (1)
Reactivities (8), (2), (2)
Applications (8), (4), (4), (3), (1)
Epitopes (1), (1)
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